ZFIN Fish: tsc2^vu242/vu242 (AB)

ZFIN ID: ZDB-FISH-150901-29460

ZFIN ID: ZDB-FISH-150901-29460

Fish name:	tsc2^vu242/vu242 (AB)
Genotype:	tsc2^vu242/vu242 (AB)
Targeting Reagent:	none

HUMAN DISEASE MODELED by tsc2^vu242/vu242 (AB)

Human Disease	Conditions	Citations
tuberous sclerosis	standard conditions	Kim et al., 2011

GENE EXPRESSION
Gene expression in tsc2^vu242/vu242 (AB)

RNA expression

Expressed Gene	Structure	Conditions	Figures
eif4ebp1	intestine kidney liver pharynx whole organism	standard conditions	Fig. 2 from Kim et al., 2011

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-rps6		whole organism	standard conditions	Fig. 2 from Kim et al., 2011
Ab1-rps6		brain eye intestine liver spinal cord	standard conditions	Fig. 2 from Kim et al., 2011
Ab1-eif4ebp1	eif4ebp1	intestine kidney liver pharynx	standard conditions	Fig. 2 from Kim et al., 2011
Ab2-eif4ebp1		whole organism	standard conditions	Fig. 2 from Kim et al., 2011

Reporter gene expression No data available

PHENOTYPE
Phenotype in tsc2^vu242/vu242 (AB)

Phenotype	Conditions	Figures
brain morphology, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
brain protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
CNS neuron (sensu Vertebrata) mislocalised, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
diencephalon anterior region disorganized, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
dorsal telencephalon disorganized, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
dorsal telencephalon increased size, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
eye protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
intestine protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
kidney protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
liver increased size, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
liver protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
negative regulation of TOR signaling disrupted, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
neuron migration disrupted, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
spinal cord protein serine/threonine kinase activity increased occurrence, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
swim bladder collapsed, abnormal	standard conditions	Fig. 2 from Kim et al., 2011
telencephalic ventricle morphology, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
telencephalic white matter composition, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
ventral telencephalon dorsal region disorganized, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
ventral telencephalon dorsal region increased width, abnormal	standard conditions	Fig. 5 from Kim et al., 2011
whole organism viability, abnormal	standard conditions	text only from Kim et al., 2011

CITATIONS (3)