ZFIN Fish: s896Tg

ZFIN ID: ZDB-FISH-150901-27585

Fish name:	s896Tg
Genotype:	s896Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by s896Tg

Human Disease	Conditions	Citations
carcinoma	cancer xenotransplantation	Berning et al., 2020
streptococcal meningitis	bacterial treatment by injection: Streptococcus pneumoniae	Jim et al., 2016

GENE EXPRESSION
Gene expression in s896Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
alcama	atrioventricular canal endocardium cell	control	Fig. 5 from Ahuja et al., 2016
cxcl8a	whole organism	standard conditions	Fig. 1 from Blaser et al., 2017
cxcr1	whole organism	standard conditions	Fig. 1 from Blaser et al., 2017
kdrl	blood vessel endothelial cell	standard conditions	Fig. 6 from Gutnick et al., 2011
mfsd2aa	brain brain vasculature	standard conditions	Figure 4 from O'Brown et al., 2019
mfsd2ab	brain brain vasculature	standard conditions	Figure 4 from O'Brown et al., 2019
otpb	(not) blood vessel endothelial cell	standard conditions	Fig. 6 from Gutnick et al., 2011
oxtra	blood vessel endothelial cell	standard conditions	Fig. 6 from Gutnick et al., 2011
plk2b	endothelial cell	chemical treatment by environment: semaxanib	Fig. S1 from Yang et al., 2015
slc2a1a	brain vasculature	standard conditions	Figure 4-figure supplement 1 from O'Brown et al., 2019

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-slc2a1		blood vessel endothelial cell central artery metencephalic artery primordial hindbrain channel	standard conditions	Fig. 7 from Ulrich et al., 2016
Ab2-rela		pronephric duct ventral wall of dorsal aorta hematopoietic stem cell	standard conditions	Fig. 5 from Espín-Palazón et al., 2014
zn-8		atrioventricular canal endocardium myocardium	control	Fig. 1 from Segert et al., 2018
Ab1-stat3		ventral wall of dorsal aorta	control	Fig. 7 from Sawamiphak et al., 2014

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
mCherry	atrioventricular canal endocardium basilar artery blood vessel blood vessel endothelial cell brain vasculature central artery dorsal aorta endocardium endothelial tip cell hypophyseal artery blood vessel endothelial cell hypophyseal capillary blood vessel endothelial cell hypophyseal vein blood vessel endothelial cell hypophysis vascular endothelium intersegmental vessel liver vasculature metencephalic artery middle mesencephalic central artery ocular blood vessel blood vessel endothelium posterior communicating artery primordial hindbrain channel retina blood vessel trunk vasculature vasculature ventral wall of dorsal aorta hematopoietic stem cell	control	21 figures from 17 publications
	central artery liver vasculature primordial hindbrain channel	chemical treatment by environment: ethanol, chemical treatment by environment: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine	Fig. 2 from Madelaine et al., 2017 Fig. 3 from Zhang et al., 2016
	blood vessel brain vasculature cranial vasculature	bacterial treatment	Fig. 3 , Fig. 5 , Fig. 7 from Jim et al., 2016 Fig. 2 from Kim et al., 2015

PHENOTYPE
Phenotype in s896Tg

Phenotype	Conditions	Figures
calcium-mediated signaling increased process quality, abnormal	mechanical stress, physical alteration: endothelial tip cell	Fig. 5 from Liu et al., 2020
central artery blood vessel lumenization decreased process quality, abnormal	chemical treatment by environment: IWR-1-endo	Fig. 2 from Hübner et al., 2018
central artery vascular sprouts decreased amount, abnormal	chemical treatment by environment: semaxanib	Fig. 2 from Madelaine et al., 2017
endothelial cell plk2b expression decreased amount, abnormal	chemical treatment by environment: semaxanib	Fig. S1 from Yang et al., 2015
liver vasculature branchiness, normal	chemical treatment by environment: ethanol	Fig. 3 from Zhang et al., 2016
liver vasculature decreased branchiness, abnormal	chemical treatment by environment: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine	Fig. 3 from Zhang et al., 2016
liver vasculature decreased branchiness, abnormal	chemical treatment by environment: ethanol	Fig. 3 from Zhang et al., 2016
liver vasculature decreased branchiness, abnormal	chemical treatment by environment: ethanol, chemical treatment by environment: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine	Fig. 3 from Zhang et al., 2016
liver vasculature diameter, normal	chemical treatment by environment: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine	Fig. 3 from Zhang et al., 2016
liver vasculature diameter, normal	chemical treatment by environment: ethanol, chemical treatment by environment: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine	Fig. 3 from Zhang et al., 2016
liver vasculature diameter, normal	chemical treatment by environment: ethanol	Fig. 3 from Zhang et al., 2016
liver vasculature increased diameter, abnormal	chemical treatment by environment: ethanol	Fig. 3 from Zhang et al., 2016
phagocyte accumulation brain, abnormal	bacterial treatment by injection: Streptococcus pneumoniae	Fig. 3 from Jim et al., 2016
response to mechanical stimulus process quality, normal	mechanical stress, physical alteration: endothelial tip cell	Fig. 5 from Liu et al., 2020
trunk vasculature increased permeability, abnormal	chemical treatment by environment: lipopolysaccharide	Fig. 2 from Philip et al., 2017
vertebral artery absent, abnormal	chemical treatment by environment: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	Fig. S4 from Matsuoka et al., 2017
vertebral artery absent, abnormal	chemical treatment by environment: wortmannin	Fig. S4 from Matsuoka et al., 2017
whole organism decreased life span, abnormal	bacterial treatment by injection: Streptococcus pneumoniae	Fig. 3 from Jim et al., 2016
whole organism intra-epithelial neoplasia present, abnormal	cancer xenotransplantation	Fig. 3 from D'Amico et al., 2018

CITATIONS (65)