ZFIN Fish: zf5Tg

ZFIN ID: ZDB-FISH-150901-24754

Fish name:	zf5Tg
Genotype:	zf5Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by zf5Tg

Human Disease	Conditions	Citations
diabetes mellitus	chemical treatment: alloxan	Nam et al., 2015

GENE EXPRESSION
Gene expression in zf5Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
ins	whole organism	standard conditions	Fig. 4 from Jurczyk et al., 2011
insb	whole organism	standard conditions	Fig. 4 from Jurczyk et al., 2011
insra	whole organism	standard conditions	Fig. 4 from Jurczyk et al., 2011
insrb	whole organism	standard conditions	Fig. 4 from Jurczyk et al., 2011
pck1	eye fin liver midbrain neural keel neuromast pharyngeal arch post-vent region tail bud whole organism yolk syncytial layer	standard conditions	Fig. 3, Fig. 4 from Jurczyk et al., 2011
pck2	(not) whole organism	standard conditions	Fig. 3 from Jurczyk et al., 2011

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-isl		posterior pancreatic bud primary islet	control	Fig. 2 from Xu et al., 2016
Ab1-ins		endocrine pancreas	standard conditions	Figure 1 from Mullapudi et al., 2018 Fig. 1 from Mazilu et al., 2010

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
GFP	endocrine pancreas endoderm exocrine pancreas pancreatic B cell insulin secreting cell pancreas pancreas primordium pancreatic B cell pancreatic bud posterior pancreatic bud unspecified	standard conditions	19 figures from 14 publications
	endocrine pancreas pancreatic B cell exocrine pancreas pancreatic B cell pancreas pancreatic B cell	chemical treatment: N-ethyl-5'-carboxamidoadenosine	Fig. 2 from Cha et al., 2018 Fig. 3 from Kwon et al., 2017 Fig. 1, Fig. 5 from Liu et al., 2017 Fig. 2 from Matsuda et al., 2017 Fig. 3 from Andersson et al., 2012

PHENOTYPE
Phenotype in zf5Tg

Phenotype	Conditions	Figures
endocrine pancreas pancreatic B cell increased amount, abnormal	chemical treatment by environment: LY-411575	Fig. 1, Fig. 5 from Liu et al., 2017
endocrine pancreas pancreatic B cell increased amount, exacerbated	chemical treatment by environment: LY-411575, chemical treatment by environment: (R)-DRF053 hydrochloride hydrate	Fig. 1, Fig. 5 from Liu et al., 2017
endocrine pancreas pancreatic B cell increased amount, exacerbated	chemical treatment by environment: LY-411575, chemical treatment by environment: seliciclib	Fig. 1 from Liu et al., 2017
pancreas GFP expression decreased amount, abnormal	chemical treatment by environment: hexadecanoic acid	Fig. 2 from Cha et al., 2018
pancreas decreased size, abnormal	chemical treatment by environment: alloxan	Fig. 3 from Kwon et al., 2017
pancreas has normal numbers of parts of type pancreatic B cell, normal	chemical treatment: N-ethyl-5'-carboxamidoadenosine	Fig. 3 from Andersson et al., 2012
pancreas has normal numbers of parts of type pancreatic B cell, normal	chemical treatment: N-ethyl-5'-carboxamidoadenosine	Fig. 3 from Andersson et al., 2012
pancreas has normal numbers of parts of type pancreatic B cell, normal	control	Fig. 3 from Andersson et al., 2012
pancreas size, ameliorated	chemical treatment by environment: isonitramine, chemical treatment by environment: alloxan	Fig. 3 from Kwon et al., 2017
pancreatic B cell GFP expression increased amount, abnormal	chemical treatment by environment: 3,3',5'-triiodothyronine	Fig. 2 from Matsuda et al., 2017
type B pancreatic cell proliferation occurrence, normal	chemical treatment: N-ethyl-5'-carboxamidoadenosine	Fig. 3 from Andersson et al., 2012
type B pancreatic cell proliferation occurrence, normal	control	Fig. 3 from Andersson et al., 2012
type B pancreatic cell proliferation occurrence, normal	chemical treatment: N-ethyl-5'-carboxamidoadenosine	Fig. 3 from Andersson et al., 2012

CITATIONS (32)