canonical Wnt signaling pathway

Term ID

GO:0060070

Synonyms

• canonical Wnt receptor signaling pathway
• canonical Wnt-activated signaling pathway
• frizzled-1 receptor signaling pathway
• Wnt receptor signaling pathway through beta-catenin
• Wnt receptor signaling pathway via beta-catenin
• Wnt receptor signalling pathway through beta-catenin

Definition

A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (2)

References

• Reactome:R-HSA-4641262

Ontology

GO: Biological Process    QuickGO    AmiGO