canonical Wnt signaling pathway

Term ID

GO:0060070

Synonyms

• canonical Wnt receptor signaling pathway
• canonical Wnt-activated signaling pathway
• frizzled-1 receptor signaling pathway
• Wnt receptor signaling pathway through beta-catenin
• Wnt receptor signaling pathway via beta-catenin
• Wnt receptor signalling pathway through beta-catenin

Definition

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (2)

References

Ontology

GO: Biological Process   QuickGO   AmiGO