intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Term ID

GO:0042771

Synonyms

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage Show first 5 Terms
negatively regulated by: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Show first 5 Terms
positively regulated by: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Show first 5 Terms
regulated by: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations