ZFIN Human Disease: acute myeloid leukemia

OBO ID: DOID:9119

Term Name:	acute myeloid leukemia		Search Ontology:
Synonyms:	acute myeloblastic leukaemia acute myeloblastic leukemia acute myelogenous leukaemia acute myelogenous leukemia acute myeloid leukaemia AML - acute Myeloid Leukemia Leukemia, Myelocytic, acute
Definition:	A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (4)
References:	GARD:12757 ICD10CM:C92.0 ICD9CM:205.0 ICDO:9861/3 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 SNOMEDCT_US_2022_09_01:17788007 UMLS_CUI:C0023467
Ontology:	Human Disease (DOID:9119)

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Alliance (1)

GENES INVOLVED

Human Gene	Zebrafish Ortholog	OMIM Term	OMIM Phenotype ID
CEBPA	cebpa	?Leukemia, acute myeloid	601626
		Leukemia, acute myeloid, somatic	601626
CHIC2	chic2	{Leukemia, acute myeloid}	601626
DNMT3A	dnmt3aa dnmt3ab	Acute myeloid leukemia, somatic	601626
ETV6	etv6	Leukemia, acute myeloid, somatic	601626
FLT3	flt3	Leukemia, acute myeloid, somatic	601626
		Leukemia, acute myeloid, reduced survival in, somatic	601626
GATA2	gata2a gata2b	{Leukemia, acute myeloid, susceptibility to}	601626
JAK2	jak2a jak2b	Leukemia, acute myeloid, somatic	601626
KIT	kitb kita	Leukemia, acute myeloid, somatic	601626
KRAS	kras	Leukemia, acute myeloid, somatic	601626
LPP	lpp	Leukemia, acute myeloid	601626
MLLT10	mllt10	Leukemia, acute myeloid	601626
NPM1	npm1a npm1b	Leukemia, acute myeloid, somatic	601626
NUP214	nup214	Leukemia, acute myeloid, somatic	601626
PICALM	picalmb picalma	Leukemia, acute myeloid, somatic	601626
RUNX1	runx1	Leukemia, acute myeloid	601626
SH3GL1	sh3gl1b sh3gl1a	Leukemia, acute myeloid	601626
TERT	tert	{Leukemia, acute myeloid}	601626

ZEBRAFISH MODELS

Fish	Conditions	Citations
AB	cancer xenotransplantation	Smith et al., 2018
TU	cancer xenotransplantation	Khan et al., 2019
WT	chemical treatment by injection: double-stranded DNA fragment	Tregnago et al., 2016
hku2Tg	standard conditions	He et al., 2020
twu101Tg (AB)	standard conditions	Lu et al., 2016
twu103Tg (AB)	standard conditions	Hou et al., 2017
twu104Tg (AB)	standard conditions	Lu et al., 2017
zf169Tg	standard conditions	Liu et al., 2017
zf685Tg	heat shock	Shen et al., 2015
asxl1^zdf34/+; tet2^zdf20/zdf20	standard conditions	Gjini et al., 2019
mitfa^w2/w2; mpv17^a9/a9	cancer xenotransplantation	Khan et al., 2018
twu101Tg; twu102Tg (AB)	standard conditions	Lu et al., 2016
twu101Tg; twu103Tg (AB)	standard conditions	Hou et al., 2017

PHENOTYPE No data available

CITATIONS (30)