Graphs showing survival factors of the experimental groups. (A) Number of fishes surviving to the end of treatments (end of 28 days) in each group. (B) Total number of days fishes survived in each group until the end of treatments (end of 28 days). Comparison of groups was performed using Kruskal-Wallis test. P > 0.05 was considered as significant. No significant differences were observed between groups. Abbreviations: HN (healthy group) Rot (rotenone), 2QRNS (drug cocktail consisting of N-acetylcysteine, resveratrol, quercetin, selenium and coenzyme Q10), NAC (N-acetylcysteine), Resv (resveratrol), Querc (quercetin), Se (selenium), CoQ10 (coenzyme Q10)

Results of locomotor activity test in the form of the number of lines crossed by zebrafish in each group before and after treatments. Data are presented as mean ± standard error of the mean. Comparison of groups was performed using ANOVA test. P > 0.05 was considered as a significant level. *P > 0.05, **P > 0.01, ***P > 0.001 indicate a significant difference with the healthy group. ^P > 0.05, ^^P > 0.01, ^^^P > 0.001 indicate a significant difference with the rotenone group. Abbreviations: HN (healthy group) Rot (rotenone), 2QRNS (drug cocktail consisting of N-acetylcysteine, resveratrol, quercetin, selenium and coenzyme Q10), NAC (N-acetylcysteine), Resv (resveratrol), Querc (quercetin), Se (selenium), CoQ10 (coenzyme Q10)

Expression levels of antioxidant genes in experimental groups. The expression levels of genes were normalized to the GAPDH gene and the data are presented as a percentage of the control group (healthy group). Comparison of groups was performed using the ANOVA test. P > 0.05 was considered as a significant level. *P > 0.05, **P > 0.01, ***P > 0.001 indicate a significant difference with the healthy group. ^P > 0.05, ^^P > 0.01, ^^^P > 0.001 indicate a significant difference with the rotenone group. Abbreviations: HN (healthy group) Rot (rotenone), 2QRNS (drug cocktail consisting of N-acetylcysteine, resveratrol, quercetin, selenium and coenzyme Q10), NAC (N-acetylcysteine), Resv (resveratrol), Querc (quercetin), Se (selenium), CoQ10 (coenzyme Q10)

Brain dopamine levels in experimental groups. the data are presented as a percentage of the control group (healthy group). Comparison of groups was performed using the ANOVA test. P > 0.05 was considered as a significant level. *P > 0.05, **P > 0.01, ***P > 0.001 indicate a significant difference with the healthy group. ^P > 0.05, ^^P > 0.01, ^^^P > 0.001 indicate a significant difference with the rotenone group. Abbreviations: HN (healthy group) Rot (rotenone), 2QRNS (drug cocktail consisting of N-acetylcysteine, resveratrol, quercetin, selenium and coenzyme Q10), NAC (N-acetylcysteine), Resv (resveratrol), Querc (quercetin), Se (selenium), CoQ10 (coenzyme Q10)