FIGURE SUMMARY
Title

BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model

Authors
Jiang, X., Wang, W., Wei, Y., Cheng, W., Li, S., Du, L., Xu, W., Zhang, Y.
Source
Full text @ J. Cosmet. Dermatol.
FIGURE 1

Effect of BAK and ARG on the area of the tail of zebrafish embryos. (A) BAK and AGR restore 0.9% NaCl‐induced water loss in the caudal fin of zebrafish embryos. The scale: 100 μm. (B) Area of the tail of zebrafish embryos. (C) Expression of AQP3 mRNA. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
FIGURE 2

Effects of BAK and ARG on the expression of ELN and COL1a1b mRNA in zebrafish embryos. (A) Expression of ELN mRNA. (B) Expression of COL1a1b mRNA. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
FIGURE 3

Effect of BAK and ARG on β‐galactosidase in zebrafish embryos. The scale: 200 μm. (A) β‐galactosidase staining of zebrafish embryos. (B) Viability of SA‐β‐Gal in zebrafish larvae. (C) Mean telomere activity. (D) Relative mRNA expression level of tert. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
FIGURE 4

Effects of BAK and ARG on oxidative stress in zebrafish embryos. The scale: 200 μm. (A) DCFH‐DA staining of zebrafish embryos. (B) Fluorescence intensity of DCFH‐DA in zebrafish embryos. (C) CAT activity. (D) MDA content. (E) SOD activity. (F) GSH activity. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
FIGURE 5

Effects of BAK and ARG on mitochondria in zebrafish embryos. (A) JC‐1 staining of zebrafish embryos. The scale: 100 μm. (B) Ratio of green/red color in the results of JC‐1 staining. (C) Fluorescence intensity of mitochondria in zebrafish. The scale: 100 μm. (D) Mean fluorescence intensity of Tg(Xla.Eef1a1: MlsEGFP) straining. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
FIGURE 6

Effects of BAK and ARG on the number of neutrophils and expression of inflammatory factors in zebrafish embryos. (A) Neutrophils in zebrafish embryos in vivo. The scale: 200 μm. (B) Mean fluorescence intensity of Tg(lyz: DsRed) zebrafish. (C) Expression of IL‐1β mRNA. (D) Expression of IL‐6 mRNA. (E) Expression of IL‐8 mRNA. (C) Expression of TNF‐α mRNA. Error bars represent mean ± SD for three replicates. Lowercase letters indicate significant differences: A, b, c, d = p < 0.05.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cosmet. Dermatol.
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