Fig. 1

Classification and domain organisation of PITP proteins found in mammals and zebrafish. PITP proteins are classified as Class I and II. Class I PITPs bind PI and PC whilst Class II PITPs bind PI and PA. The transcriptional variants of PITPĪ² and PITPNC1 are indicated. In zebrafish, Pitpnc1 is expressed from two separate genes present on different chromosomes.

Fig. 2

Binding partners of PITPNC1. The PITP domain circled in red can bind to the adaptor protein, ATRAP and to HSC70. The C-terminal extension contains the residues, Ser274 and Ser299 which bind to 14-3-3 proteins when phosphorylated. The binding site of Rab1B is not known but it binds more strongly to Pitpnc1 when the phospho-sites on the C-terminus are mutated.

Acknowledgments
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