FIGURE SUMMARY
Title

Assessing developmental toxicity and non-CYP mediated biotransformation of two anti-epileptics and their human metabolites in zebrafish embryos and larvae

Authors
Hoyberghs, J., Coppens, A., Bars, C., Van Ginneken, C., Foubert, K., Van Cruchten, S.
Source
Full text @ Curr Res Toxicol
Fig. 1

Proposed pathway of carbamazepine in humans by myeloperoxidases in activated leukocytes

Fig. 2

Proposed pathway of carbamazepine in humans. Metabolism in the liver is indicated with broken arrows. Metabolism in the peripheral blood is indicated with continuous arrows

Fig. 3

Larvae exposed to CBZ or AI at 120 hpf. A) Control larva (1 % DMSO) showing no signs of abnormalities. B) Larva treated with 250 µM CBZ. C) Larva treated with 500 µM CBZ. D) Larva treated with 30 µM AI. The larvae depicted in B, C and D show several malformations. Abbreviations: acridine (AI), carbamazepine (CBZ), edema eyes (EE), edema head (EH), edema pericard (EP), increased pigmentation (IP), malformation yolk (MY), no hatching (NH).

Fig. 4

Larvae exposed to AO or 9ACA at 120 hpf. A) Control larva (1 % DMSO) showing no signs of abnormalities. B) Larva treated with 30 µM AO. C) Larva treated with 60 µM AO. D) Larva treated with 30 µM 9ACA. E) Larva treated with 60 µM 9ACA. The larvae depicted in B, C, D and E show several malformations. Abbreviations: 9-acridine carboxaldehyde (9ACA), acridone (AO), curved tail (CT), deviation eyes (shape) (DES), edema eyes (EE), edema head (EH), edema pericard (EP), increased pigmentation (IP), malformation yolk (bigger) (MYB), no hatching (NH).

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr Res Toxicol
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