FIGURE SUMMARY
Title

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

Authors
Yu, Z.W., Cai, B.P., Xie, S.Z., Zhang, Y., Wang, W.H., Liu, S.Z., Bin, Y.L., Chen, Q., Fang, M.J., Qi, R., Li, M.Y., Qiu, Y.K.
Source
Full text @ Nat Prod Bioprospect
Fig. 1

Structure of isolated compounds from the woods of Agathisdammara (*new compounds)
Fig. 2

Structural elucidation of compounds 16, 17. A COSY and key HMBC signals. B NOESY correlations and relative configurations. C ECD spectral of 16, 17 versus calculated values
Fig. 3

Biological evaluation and mechanism study of the hypoglycaemic activity of isolated compounds. A Blood glucose value of hyperglycaemic zebrafish model after treatment with compounds 1–17 for 24 h. B ED50 value calculation of the hypoglycaemic activity of compounds 5, 11, 14. C Changes in the number of pancreatic β cells in the hyperglycaemic zebrafish model after treatment with compounds 5, 11, 14 for 24 h. D Changes in the 2-NBDG uptake ability of the hyperglycaemic zebrafish model after treatment with compounds 5, 11, 14 for 24 h. (*p < 0.05; **p < 0.01; ***p < 0.001)
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat Prod Bioprospect
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