PUBLICATION
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
- Authors
- Yu, Z.W., Cai, B.P., Xie, S.Z., Zhang, Y., Wang, W.H., Liu, S.Z., Bin, Y.L., Chen, Q., Fang, M.J., Qi, R., Li, M.Y., Qiu, Y.K.
- ID
- ZDB-PUB-240323-1
- Date
- 2024
- Source
- Natural products and bioprospecting 14: 2323 (Journal)
- Registered Authors
- Keywords
- Agathis dammara, Glucose uptake, Hypoglycaemic, Lignans, Terpenes
- MeSH Terms
- none
- PubMed
- 38517590 Full text @ Nat Prod Bioprospect
Citation
Yu, Z.W., Cai, B.P., Xie, S.Z., Zhang, Y., Wang, W.H., Liu, S.Z., Bin, Y.L., Chen, Q., Fang, M.J., Qi, R., Li, M.Y., Qiu, Y.K. (2024) Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others. Natural products and bioprospecting. 14:2323.
Abstract
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1-12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping