FIGURE SUMMARY
Title

Effects of carnosine on the embryonic development and TiO2 nanoparticles-induced oxidative stress on Zebrafish

Authors
Caruso, G., Scalisi, E.M., Pecoraro, R., Cardaci, V., Privitera, A., Truglio, E., Capparucci, F., Jarosova, R., Salvaggio, A., Caraci, F., Brundo, M.V.
Source
Full text @ Front Vet Sci
Figure 1

Effects of increasing concentrations of carnosine (0.1, 1, 10, and 20 mM) on the phenotypes of both embryos and larvae at different (4, 24, 48, and 72) hpf. Car, carnosine.
Figure 2

Beats per minute (BPM) of unexposed larvae and larvae exposed to increasing concentrations of carnosine (0.1, 1, 10, and 20 mM). SD is represented by vertical bars. Car, carnosine; n.s., not significant.
Figure 3

Body length (μm) of unexposed larvae and larvae exposed to increasing concentrations of carnosine (0.1, 1, 10, and 20 mM). SD is represented by vertical bars. Car, carnosine; n.s., not significant.
Figure 4

Effects of TiO2-NPs on the phenotypes of both embryos and larvae at different (4, 24, 48, and 72) hpf.
Figure 5

Total ROS production in (A) untreated larvae, (B) TiO2-NPs-treated larvae, and (C) TiO2-NPs-treated larvae in the presence of carnosine 20 mM (1 h pre-treatment). Carnosine was kept during the exposure to TiO2-NPs. The average fluorescence intensity (AU) of at least 5 values for fixed larva is reported in (D). SD is represented by vertical bars. ***Significantly different, p < 0.001. n.s., not significant.
Figure 6

Hsp70 expression levels in (A) untreated larvae, (B) TiO2-NPs-treated larvae, and (C) TiO2-NPs-treated larvae in the presence of carnosine 20 mM (1 h pre-treatment). Carnosine was kept during the exposure to TiO2-NPs. The average fluorescence intensity (AU) of at least 5 values for fixed larva is reported in (D). SD is represented by vertical bars. ***Significantly different, p < 0.001.
Figure 7

MTs expression levels in (A) untreated larvae, (B) TiO2-NPs-treated larvae, and (C) TiO2-NPs-treated larvae in the presence of carnosine 20 mM (1 h pre-treatment). Carnosine was kept during the exposure to TiO2-NPs. The average fluorescence intensity (AU) of at least 4 values for fixed larva is reported in (D). SD is represented by vertical bars. *Significantly different, p < 0.05; **Significantly different, p < 0.01; n.s., not significant.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Vet Sci
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.