FIGURE SUMMARY
Title

Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues

Authors
Cerveny, K.L., Bronstein, H., Hagen, O., Lamb, D.B., Martin, G., Tower, I., Van Duzer, A., Welch, E., Varga, M.
Source
Full text @ MicroPubl Biol
Figure 1

Figure 1 Survival and/or differentiation of ahctf1, ssrp1a, and fbxo5 mutant cells can be altered by a wild-type developing retinal environment:

A-F Representative images of frontal cryosections of 3 dpf chimeric wild-type (wt) retinae containing GFP-labelled wild-type (A), hdac1 mutant (B), ahctf1 mutant (C), ssrp1a mutant (D) or fbxo5 mutant (E-F) cells immunostained for GFP (green cells from donor embryo) and beta-catenin (red cell boundaries and plexiform layers).

G-H Lateral views of single 2µm-thick z-plane of whole-mount 3 dpf chimeric wild-type retinae containing wild-type (G) or gins2 morphant (H) cells labeled with membrane-targeted RFP. H’ shows 3x enlargement of boxed region in H.

I-J Lateral maximum intensity projection of ~50 hpf retinae from Tg[atoh7:GFP] embryos showing neurogenic gene expression in wild-type (I) or fbxo5 mutant (J) retinae.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ MicroPubl Biol
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