Figure 1

Chromatograms of 2-picolinic acid (PA)-derivatized 5-α dihydrotestosterone (DHT) and DHT-D3.

Figure 2

Quantitative PCR analysis for measuring the mRNA expression levels of SRD5A1 and SRD5A2 in the LNCaP, DU-145, and SW-13 cell lines. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.

Figure 3

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on LNCaP, DU-145, and SW-13 cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.

Figure 3 cont.

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on LNCaP, DU-145, and SW-13 cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.

Figure 4

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on transfected HEK-293 cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.

Figure 4 cont.

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on transfected HEK-293 cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.

Figure 5

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on and zebrafish liver cells (ZFL) and rainbow trout gonad (RTG-2) cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.
Figure 5 cont.

Activity of 5α-reductase (a) and inhibitory effects of finasteride and dutasteride (b) on and zebrafish liver cells (ZFL) and rainbow trout gonad (RTG-2) cells. The data are expressed as the mean ± standard deviation (SD) of three repeated experiments.
Acknowledgments
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