FIGURE SUMMARY
Title

Screening Study on the Anti-Angiogenic Effects of Traditional Chinese Medicine - Part II: Wild Chrysanthemum

Authors
Tu, X., Wang, H.B., Huang, Q., Cai, Y., Deng, Y.P., Yong, Z., Hu, Q., Feng, J., Jordan, J.B., Zhong, S.
Source
Full text @ J Cancer
Figure 1

WCWE showed a significant anti-angiogenic effect in zebrafish. Compared with vehicle controls, the zebrafish embryo treated by WCWE showed a significant angiogenesis defect (panel A1, B-J). An image at higher magnification showed that the larvae treated with WCWE presents a lower number of complete ISVs (panel A2).
Figure 2

Vehicle controls. DMSO served as a vehicle control. Vehicle controls did not show a significant angiogenesis defect (panel A-D).
Figure 3

Positive controls. 5μg/ml PTK 787 showed a more potent anti-angiogenic effect than WCWE.
Figure 4

Volcano Plot. Volcano plot of the genes regulated by WCWE.
Figure 5

Results of qRT-PCR assay. The relative genetic expression levels of the ten genes involving proteasome signaling pathway. There was significant differences between the vehicle control group and the WCWE group in all ten genes (* indicates P < 0.05).
Figure 6

Results of PRM assay. Peptide fragments ion peak area distribution of the nine significantly changed proteins in the proteasome signaling and β-catenin (panel A: psmc6; panel B1-2: psmc2; panel C: psmd4a; panel D1-2: psmd7; panel E: psmc3; panel F1-2: psmc5; panel G: psmd1; panel H: psmd12; panel I: psmd6; panel J1-2: ctnnb2).
Figure 7

Proteasome signaling pathway regulated by WCWE. WCWE significantly down-regulated the genes involved in the proteasome signaling pathway. Green marked nodes are associated with down-regulated genes. Panel A is the KEGG pathway analysis based on the mRNA-seq assay. Panel B is the KEGG pathway analysis based on the PRM assay.
Figure 8

HPLC assay results. Four chromatographic peaks of WCWE were identified.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cancer
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