FIGURE SUMMARY
Title

Identification of novel susceptibility loci for non-syndromic cleft lip with or without cleft palate

Authors
Ma, L., Lou, S., Miao, Z., Yao, S., Yu, X., Kan, S., Zhu, G., Yang, F., Zhang, C., Zhang, W., Wang, M., Wang, L., Pan, Y.
Source
Full text @ J. Cell. Mol. Med.
Fig. S6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Figure 1

Flow chart of this study
Figure 2

Regional plot of the five newly identified SNPs. The regional plots indicate five variants (A) rs11119445, (B) rs227227, (C) rs12561877, (D) rs643118 and (E) rs2095293 and linkage disequilibrium structure. Logistic regression analyses were used to test the genetic association under an additive model. The marker SNPs are shown as purple diamonds with P values in primary GWAS meta and as with their P values in the combined stage when all of the NSCL/P cases and controls from the primary GWAS meta and replication I, II were pooled together. Points are colour‐coded based on linkage disequilibrium (r2) in Asians. For each plot, the recombination rates (right y‐axes) of the region are shown according to their chromosomal positions (x‐axis)
Figure 3

Comparison of associations for the six genetic variants in Asian and European ancestry populations. Pheterogeneity was calculated to test the difference in the association of each of the SNPs with risk of NSCL/P across these two populations
Figure 4

Zebrafish larvae were imaged with transmitted light. (A) Translation‐blocking morpholino and CRISPR/Cas9‐based targeted sertad4 knockdown (crispant) zebrafish models, (B) Embryos with over‐expression of human NR6A1 or zebrafish nr6a1a. Mandibular indicated by red dotted line

PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Protruding-mouth to Day 4
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.