FIGURE SUMMARY
Title

Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol

Authors
de Carvalho, T.S., Cardoso, P.B., Santos-Silva, M., Lima-Bastos, S., Luz, W.L., Assad, N., Kauffmann, N., Passos, A., Brasil, A., Bahia, C.P., Moraes, S., Gouveia, A., de Jesus Oliveira Batista, E., Oliveira, K.R.M.H., Herculano, A.M.
Source
Full text @ Oxid Med Cell Longev
Figure 1

Effect of caffeine on (a) time spent in the white compartment, (b) erratic swimming, (c) risk assessment, (d) latency, (e) squares crossed, and (f) thigmotaxis in the scototaxis test. Bar graphs represent the mean ± standard error. Data were compared using the ANOVA-one way test followed by the Tukey test. ∗p < 0.05 vs. control.
Figure 2

Effect of caffeine on (a) time on the top, (b) squares crossed, (c) erratic swimming, and (d) latency on the top in the geotaxy test. Bar graphs represent the mean ± standard error. Data were compared using the ANOVA-one way test followed by the Tukey test. ∗∗p < 0.05 vs. control and #p < 0.05 vs. caffeine group.
Figure 3

Effect of alpha-tocopherol on (a) time spent in the white compartment, (b) erratic swimming, (c) risk assessment, (d) latency, (e) squares crossed, and (f) thigmotaxis in the scototaxis of zebrafish treated with caffeine. Bar graphs represent the mean ± standard error. Data were compared using the ANOVA-one way test followed by the Tukey test. ∗p < 0.05 vs. control and #p < 0.05 vs. caffeine group.
Figure 4

Effect of alpha-tocopherol on (a) time on the top, (b) squares crossed, (c) erratic swimming, and (d) latency on the top in the geotaxy of zebrafish treated with caffeine. Bar graphs represent the mean ± standard error. Data were compared using the ANOVA-one way test followed by the Tukey test. ∗p < 0.05 and ∗∗p < 0.05 vs. control and #p < 0.05 vs. caffeine group.
Figure 5

Lipid peroxidation in the brain of zebrafish treated with caffeine or caffeine and alpha-tocopherol. Data are expressed as percent of control and compared using the ANOVA-one way test followed by the Tukey test. ∗p < 0.01 vs. control.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oxid Med Cell Longev
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