FIGURE SUMMARY
- Title
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Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro
- Authors
- Saarenpää, T., Kogan, K., Sidorova, Y., Mahato, A.K., Tascón, I., Kaljunen, H., Yu, L., Kallijärvi, J., Jurvansuu, J., Saarma, M., Goldman, A.
- Source
- Full text @ PLoS One
zGDNF supports the survival of cultured mammalian dopaminergic neurons. (A) the counted number of embryonic dopaminergic neurons in the presence of zGDNF and hGDNFIC versus negative control (media), (B) immunofluorescent staining of midbrain culture on 5DIV with a marker for DA neurons: TH (red) and nuclear dye DAPI (blue) comparing 0.27 nM of hGDNFIC, zGDNF and no GFL (control). Black bars: zGDNF; red bars: hGDNFIC; white bar: negative control. N = 4 indiviaul experiments per condition; statistically different from control ***p< 0.0007, **p< 0.003, *p<0.03. |
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Full text @ PLoS One