FIGURE SUMMARY
Title

Early embryonic gene expression profiling of zebrafish prion protein (prp2) morphants

Authors
Nourizadeh-Lillabadi, R., Seilø Torgersen, J., Vestrheim, O., König, M., Aleström, P., and Syed, M.
Source
Full text @ PLoS One
Fig. 2

Larvae were immobilized in CyGEL prior to microscopy. A) Non-injected wt control. B–D) three individual morphants displaying defective midbrain and hindbrain development.

PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-5
Fig. 3

Neuronal structures were visualized by the Zn12 antibody (Yellow), whereas Prp2 was detected with a rabbit anti serum (Red). A) In the wild type 24 hpf Prp2 is observed in the trigeminal ganglion and telencephalon, but also present in other neuronal tissue. B) Neuronal structures visualized by HNK-1 staining (Zn-12 antibody) in the same specimen as in A. C) Aberrant morphology of the trigeminal ganglion in Prp2 morphants (arrow) as well as reduced number of peripheral neurons visualized by HNK-1 staining. D) Non deconvolved single plane image of a morphant with condensed nuclei (inside stippled ring). Abbreviations: eye (e), telencephalon (t) and trigeminal ganglion (tg).

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One
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