FIGURE SUMMARY
Title

Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay

Authors
Wei, X., Bugni, T.S., Harper, M.K., Sandoval, I.T., Manos, E.J., Swift, J., Van Wagoner, R.M., Jones, D.A., and Ireland, C.M.
Source
Full text @ Mar. Drugs
Fig. 2

Amphimedine-treated embryos exhibit heart, yolk and body shape defects. Treatment of embryos seven hours post-fertilization (hpf) with 30 μM amphimedine (amp) resulted in pericardial edema (arrow), extended heart (arrow head), enlarged yolk with thin extension (*), curving of the body and general necrosis at 24 hours post-treatment (hpt; B) and 48 hpt (D) compared to the DMSO-treated controls (A and C, respectively).

Fig. 3

Additional developmental defects resulting from amphimedine treatment. In situ hybridization was performed on control (A, C, E, G, I, K, M, O, Q) and treated (B, D, F, H, J, L, N, P, R) embryos harvested at 24 h (ntl, hnf6, myoD, dlx2, otx2, fgf8, zash1a, id6) or 48 h (crx) post treatment. Scale bars, 50 μM. not, notochord; sc, spinal cord; som, somites; pa, pharyngeal arches; fb, forebrain; mb, midbrain; mhb, mid/hindbrain boundary; hb, hindbrain; pfb, pectoral fin bud; e, eye.

Acknowledgments
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Open Access.
Full text @ Mar. Drugs
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