Gene

invs

ID

ZDB-GENE-020507-2

Name

inversin

Symbol

invs Nomenclature History

Previous Names

wu:fe47e11

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have calmodulin binding activity. Involved in several processes, including morphogenesis of an epithelium; opsin transport; and urogenital system development. Localizes to cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in nephronophthisis 2. Orthologous to human INVS (inversin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Simons et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With invs Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephronophthisis 2	Alliance	Nephronophthisis 2, infantile	602088

Associated With invs Via Experimental Models

Human Disease	Fish	Conditions	Citations
ciliopathy	WT + MO3-invs	control	Tobin et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat