ZFIN ID: ZDB-PERS-110520-1
Giacomotto, Jean
Email: giacomottojean@gmail.com
URL: http://https://sites.google.com/site/giacomottojean/areas-of-interest
Affiliation: Psychiatric Genomics, Prof. Bryan Mowry laboratory
Address: Queensland Brain Institute The University of Queensland - St Lucia Honorary affiliate of Sydney Medical School Brain & Mind Research Institute
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Phone: +61 2 9114 4208
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BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Lim, Y.W., Lo, H.P., Ferguson, C., Martel, N., Giacomotto, J., Gomez, G.A., Yap, A.S., Hall, T.E., Parton, R.G. (2017) Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development. Current biology : CB. 27(13):1968-1981.e7
Giacomotto, J., Carroll, A.P., Rinkwitz, S., Mowry, B., Cairns, M.J., Becker, T.S. (2016) Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish. Translational psychiatry. 6:e818
Svahn, A.J., Giacomotto, J., Graeber, M.B., Rinkwitz, S., Becker, T.S. (2016) miR-124 contributes to the functional maturity of microglia. Developmental Neurobiology. 76(5):507-18
Laird, A.S., Mackovski, N., Rinkwitz, S., Becker, T.S., Giacomotto, J. (2016) Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages. Human Molecular Genetics. 25(9):1728-38
Ishibashi, M., Manning, E., Shoubridge, C., Krecsmarik, M., Hawkins, T.A., Giacomotto, J., Zhao, T., Mueller, T., Bader, P.I., Cheung, S.W., Stankiewicz, P., Bain, N.L., Hackett, A., Reddy, C.C., Mechaly, A.S., Peers, B., Wilson, S.W., Lenhard, B., Bally-Cuif, L., Gecz, J., Becker, T.S., Rinkwitz, S. (2015) Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene. Human genetics. 134(11-12):1163-82
Himaya, S.W., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F., Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of Proteome Research. 14(10):4372-81
Giacomotto, J., Rinkwitz, S., Becker, T.S. (2015) Effective heritable gene knockdown in zebrafish using synthetic microRNAs. Nature communications. 6:7378
Punnamoottil, B., Rinkwitz, S., Giacomotto, J., Svahn, A.J., Becker, T.S. (2015) Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of SLIT2/3 genes. Genesis (New York, N.Y. : 2000). 53(5):321-8
Giacomotto, J., Brouilly, N., Walter, L., Mariol, M.C., Berger, J., Ségalat, L., Becker, T.S., Currie, P.D., and Gieseler, K. (2013) Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy. Hum. Mol. Genet.. 22(22):4562-78
Djiotsa, J., Verbruggen, V., Giacomotto, J., Ishibashi, M., Manning, E., Rinkwitz, S., Manfroid, I., Lvoz, M., and Peers, B. (2012) Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Developmental Biology. 12(1):37
Giacomotto, J., and Ségalat, L. (2010) High-throughput screening and small animal models, where are we?. British journal of pharmacology. 160(2):204-216

NON-ZEBRAFISH PUBLICATIONS
Caenorhabditis elegans as a chemical screening tool for the study o f neuromuscular disorders. Manual and semi-automated methods.
Giacomotto J, Ségalat L, Carre-Pierrat M, Gieseler K.
Methods. 2011 Oct 21. [Epub ahead of print]

Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.
Giacomotto, J; Pertl, C; Borrel, C, et al.
HUMAN MOLECULAR GENETICS Volume: 18 Issue: 21 Pages: 4089-4101 Published: 2009

Metabolic Profiling Strategy of Caenorhabditis elegans by Whole-Organism Nuclear Magnetic Resonance
Blaise*, BJ; Giacomotto*, J; Triba*, MN, et al.
JOURNAL OF PROTEOME RESEARCH Volume: 8 Issue: 5 Pages: 2542-2550 Published: 2009

Metabotyping of Caenorhabditis elegans reveals latent phenotypes
Blaise, BJ; Giacomotto, J; Elena, B, et al.
PNAS Volume: 104 Issue: 50 Pages: 19808-19812 Published: 2007

Blocking of striated muscle degeneration by serotonin in C. elegans
Carre-Pierrat, M; Mariol, MC; Chambonnier, L, et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY Volume: 27 Issue: 3-4 Pages: 253-258 Published: MAR 2006