PUBLICATION
Brain-wide visual habituation networks in wild type and fmr1 zebrafish
- Authors
- Marquez-Legorreta, E., Constantin, L., Piber, M., Favre-Bulle, I.A., Taylor, M.A., Blevins, A.S., Giacomotto, J., Bassett, D.S., Vanwalleghem, G.C., Scott, E.K.
- ID
- ZDB-PUB-220219-1
- Date
- 2022
- Source
- Nature communications 13: 895 (Journal)
- Registered Authors
- Giacomotto, Jean, Scott, Ethan
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Brain Waves/physiology
- Calcium/analysis
- Habituation, Psychophysiologic/physiology*
- Larva/physiology
- Mesencephalon/physiology*
- Neurons/physiology
- RNA-Binding Proteins/genetics
- RNA-Binding Proteins/metabolism*
- Reflex, Startle/physiology
- Zebrafish/embryology
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 35173170 Full text @ Nat. Commun.
Citation
Marquez-Legorreta, E., Constantin, L., Piber, M., Favre-Bulle, I.A., Taylor, M.A., Blevins, A.S., Giacomotto, J., Bassett, D.S., Vanwalleghem, G.C., Scott, E.K. (2022) Brain-wide visual habituation networks in wild type and fmr1 zebrafish. Nature communications. 13:895.
Abstract
Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circuit that habituates minimally, a moderately habituating midbrain population proposed to mediate the sensorimotor transformation, and downstream circuit elements responsible for higher order representations and the delivery of behavior. Zebrafish larvae carrying a mutation in the fmr1 gene have a systematic shift toward sustained premotor activity in this network, and show slower behavioral habituation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping