ZFIN ID: ZDB-LAB-970417-32
Carvan Lab
PI/Director: Carvan III, Michael J.
Contact Person: Carvan III, Michael J.
Email: carvanmj@uwm.edu
URL: http://www.uwm.edu/Dept/GLWI/
Address: Wisconsin Aquatic Technology and Environmental Research Institute Great Lakes WATER Institute University of Wisconsin Milwaukee 600 East Greenfield Avenue Milwaukee, WI 53204 USA
Country: United States
Phone: (414) 382-1706
Fax: (414) 382-1705
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
The primary interests of the laboratory involve xenobiotic-inducible genes, their mechanism(s) of regulation, and their function in normal cellular physiology. Current emphasis is on 1) the developmental effects of ethanol, persistent chemical pollutants like dioxin and mercury, and neurotoxic pesticides; 2) receptor-dependent interactions with DNA response elements (especially those that respond to metals, aromatic hydrocarbons, and oxidative stress)and their role in transcriptome responses; and 3) identification of genes that influence sensitivity and resistance to the effects of environmental chemicals.


LAB MEMBERS
Klingler, Rebekah Henderson Post-Doc Liu, Qing Graduate Student Oluyemi, Afolayan


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Berg, C., Carvan, M., Hesselbach, R., Luo, Z., Petering, D., Pickart, M., Tomasiewicz, H., Weber, D., Shukla, R., Goldberg, B. (2021) Meeting the COVID Challenge to a Research-intensive Pre-college Science Education Program. Journal of STEM outreach. 4(2)
Li, D., Xie, L., Carvan, M.J., Guo, L. (2019) Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish. Environmental pollution (Barking, Essex : 1987). 252:616-626
Ding, C., Liu, Q., Li, J., Ma, J., Wang, S., Dong, Q., Xu, D., Qiu, J., Wang, X. (2019) Attenuated Listeria monocytogenes protecting zebrafish (Danio rerio) against Vibrio species challenge. Microbial pathogenesis. 132:38-44
DeBofsky, A.R., Klingler, R.H., Mora-Zamorano, F.X., Walz, M., Shepherd, B., Larson, J.K., Anderson, D., Yang, L., Goetz, F., Basu, N., Head, J., Tonellato, P., Armstrong, B.M., Murphy, C., Carvan, M.J. (2017) Female reproductive impacts of dietary methylmercury in yellow perch (Perca flavescens) and zebrafish (Danio rerio). Chemosphere. 195:301-311
Carvan, M.J., Kalluvila, T.A., Klingler, R.H., Larson, J.K., Pickens, M., Mora-Zamorano, F.X., Connaughton, V.P., Sadler-Riggleman, I., Beck, D., Skinner, M.K. (2017) Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish. PLoS One. 12:e0176155
Zhang, Y., Ke, Y., Zheng, X., Liu, Q., Duan, X. (2017) Correlation between genotype and phenotype in three families with Peutz-Jeghers Syndrome. Experimental and Therapeutic Medicine. 13(2):507-514
Liu, Q., Klingler, R.H., Wimpee, B., Dellinger, M., King-Heiden, T., Grzybowski, J., Gerstenberger, S.L., Weber, D.N., Caravan, M.J. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:272-282
Mora-Zamorano, F.X., Klingler, R., Murphy, C., Basu, N., Head, J.H., Carvan III, M.J. (2016) Parental whole life cycle exposure to dietary methylmercury in zebrafish (Danio rerio) affects the behavior of offspring. Environmental science & technology. 50(9):4808-16
Mora-Zamorano, F.X., Svoboda, K.R., Carvan, M.J. (2016) The Nicotine-Evoked Locomotor Response: A Behavioral Paradigm for Toxicity Screening in Zebrafish (Danio rerio) Embryos and Eleutheroembryos Exposed to Methylmercury. PLoS One. 11:e0154570
Wilson, C.A., High, S.K., McCluskey, B.M., Amores, A., Yan, Y.L., Titus, T.A., Anderson, J.L., Batzel, P., Carvan, M.J., Schartl, M., Postlethwait, J.H. (2014) Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains. Genetics. 198(3):1291-308
Tomasiewicz, H.G., Hesselbach, R., Carvan, M.J., Goldberg, B., Berg, C.A., Petering, D.H. (2014) Zebrafish as a Model System for Environmental Health Studies in the Grade 9-12 Classroom. Zebrafish. 11(4):384-95
Liu, Q., Spitsbergen, J.M., Cariou, R., Huang, C.Y., Jiang, N., Goetz, G., Hutz, R.J., Tonellato, P.J., Carvan, M.J. (2014) Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. PLoS One. 9:e100910
Flentke, G.R., Klingler, R.H., Tanguay, R.L., Carvan, M.J., and Smith, S.M. (2014) An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcoholism, clinical and experimental research. 38(5):1255-65
Liu, Q., Basu, N., Goetz, G., Jiang, N., Hutz, R.J., Tonellato, P.J., and Carvan, M.J. (2013) Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology (London, England). 22(4):740-51
Xu, X., Weber, D., Carvan, M.J., Coppens, R., Lamb, C., Goetz, S., and Schaefer, L.A. (2012) Comparison of neurobehavioral effects of methylmercury exposure in older and younger adult zebrafish (Danio rerio). Neurotoxicology. 33(5):1212-1218
Frost, F., Craun, G., Brown, K.G., Wartenberg, D., Scott, C.S., Ladero, J.M., Nebert, D.W., Stuart, G.W., Solis, W.A., and Carvan, M.J. III (2011) EHP 110-1, 2002: Correspondence. Environmental health perspectives. 110(1):2-15
Smith, L.E., Carvan, M.J. 3rd, Dellinger, J.A., Ghorai, J.K., White, D.B., Williams, F.E., and Weber, D.N. (2010) Developmental selenomethionine and methylmercury exposures affect zebrafish learning. Neurotoxicology and teratology. 32(2):246-255
Carvan III, M.J., Incardona, J.P., and Rise, M.L. (2008) Meeting the Challenges of Aquatic Vertebrate Ecotoxicology. Bioscience. 58(11):1015-1025
Weber, D.N., Connaughton, V.P., Dellinger, J.A., Klemer, D., Udvadia, A., and Carvan, MJ 3rd. (2008) Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiology & behavior. 93(1-2):250-260
Aleström, P., Begemann, G., Carvan, M.J. 3rd, Cheng, K.C., Crosier, K., Crosier, P., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G., Mione, M., Neely, M.N., Neuhauss, S., and Trede, N.S. (2008) Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24
Heiden, T.C., Struble, C.A., Rise, M.L., Hessner, M.J., Hutz, R.J., and Carvan, M.J. 3rd. (2008) Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD-induced endocrine disruption and reproductive toxicity. Reproductive toxicology (Elmsford, N.Y.). 25(1):47-57
Pullela, P.K., Chiku, T., Carvan, M.J. 3rd, and Sem, D.S. (2006) Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes. Analytical biochemistry. 352(2):265-273
Arenzana, F.J., Carvan, M.J. 3rd, Aijon, J., Sanchez-Gonzalez, R., Arevalo, R., and Porteros, A. (2006) Teratogenic effects of ethanol exposure on zebrafish visual system development. Neurotoxicology and teratology. 28(3):342-348
King Heiden, T., Carvan, M.J., 3rd, and Hutz, R.J. (2006) Inhibition of Follicular Development, Vitellogenesis and Serum 17{beta} Estradiol Concentrations in Zebrafish Following Chronic, Sublethal Dietary Exposure to 2,3,7,8,-Tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 90(2):490-499
Hutz, R.J., Carvan, M.J., Baldridge, M.G., Conley, L.K., and Heiden, T.K. (2006) Environmental toxicants and effects on female reproductive function. Trends in reproductive biology. 2:1-11
Heiden, T.K., Hutz, R.J., and Carvan, M.J. 3rd. (2005) Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 87(2):497-507
Carvan, M.J. III, Loucks, E., Weber, D.N., and Williams, F.E. (2004) Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicology and teratology. 26(6):757-768
Loucks, E., and Carvan, M.J. III (2004) Strain-dependent effects of developmental ethanol exposure in zebrafish. Neurotoxicology and teratology. 26(6):745-755
Postlethwait, J., Ruotti, V., Carvan, M.J., and Tonellato, P.J. (2004) Automated analysis of conserved syntenies for the zebrafish genome. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:255-271
Nebert, D.W., Stuart, G.W., Solis, W.A., and Carvan, M.J. III (2002) Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution. Environmental health perspectives. 110(1):A15
Dasmahapatra, A.K., Doucet, H.L., Bhattacharyya, C., Carvan III, M.J. (2001) Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 286(5):1082-1086
Carvan III, M.J., Sonntag, D.M., Cmar, C.B., Cook, R.S., Curran, M.A., and Miller, G.L. (2001) Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. The Science of the total environment. 274(1-3):183-196
Dalton, T.P., Solis, W.A., Nebert, D.W., and Carvan, M.J., III (2000) Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 126(3):325-335
Carvan III, M.J., Solis, W.A., Gedamu, L., and Nebert, D.W. (2000) Activation of transcription factors in zebrafish cell cultures by environmental pollutants. Archives of biochemistry and biophysics. 376(2):320-327
Carvan III, M.J., Dalton, T.P., Stuart, G.W., and Nebert, D.W. (2000) Transgenic zebrafish as sentinels for aquatic pollution. Annals of the New York Academy of Sciences. 919:133-147