ZFIN Person: Carvan III, Michael J.

ZFIN ID: ZDB-PERS-960805-94

ZFIN ID: ZDB-PERS-960805-94

Carvan III, Michael J.

Email:	carvanmj@uwm.edu
URL:	http://www.uwm.edu/~carvanmj/
Affiliation:	Carvan Lab
Address:	Wisconsin Aquatic Technology and Environmental Research Institute Great Lakes WATER Institute University of Wisconsin Milwaukee 600 East Greenfield Avenue Milwaukee, WI 53204 USA
Country:	United States
Phone:	(414) 382-1706
Fax:	(414) 382-1705
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

The primary interests of the laboratory involve xenobiotic-inducible genes, their mechanism(s) of regulation, and their function in normal cellular physiology. Current emphasis is on 1) the developmental effects of ethanol, persistent chemical pollutants like dioxin and mercury, and neurotoxic pesticides; 2) receptor-dependent interactions with DNA response elements (especially those that respond to metals, aromatic hydrocarbons, and oxidative stress)and their role in transcriptome responses; and 3) identification of genes that influence sensitivity and resistance to the effects of environmental chemicals.

PUBLICATIONS

Berg, C., Carvan, M., Hesselbach, R., Luo, Z., Petering, D., Pickart, M., Tomasiewicz, H., Weber, D., Shukla, R., Goldberg, B. (2021) Meeting the COVID Challenge to a Research-intensive Pre-college Science Education Program. Journal of STEM outreach. 4(2)

Li, D., Xie, L., Carvan, M.J., Guo, L. (2019) Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish. Environmental pollution (Barking, Essex : 1987). 252:616-626

DeBofsky, A.R., Klingler, R.H., Mora-Zamorano, F.X., Walz, M., Shepherd, B., Larson, J.K., Anderson, D., Yang, L., Goetz, F., Basu, N., Head, J., Tonellato, P., Armstrong, B.M., Murphy, C., Carvan, M.J. (2017) Female reproductive impacts of dietary methylmercury in yellow perch (Perca flavescens) and zebrafish (Danio rerio). Chemosphere. 195:301-311

Carvan, M.J., Kalluvila, T.A., Klingler, R.H., Larson, J.K., Pickens, M., Mora-Zamorano, F.X., Connaughton, V.P., Sadler-Riggleman, I., Beck, D., Skinner, M.K. (2017) Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish. PLoS One. 12:e0176155

Mora-Zamorano, F.X., Klingler, R., Murphy, C., Basu, N., Head, J.H., Carvan III, M.J. (2016) Parental whole life cycle exposure to dietary methylmercury in zebrafish (Danio rerio) affects the behavior of offspring. Environmental science & technology. 50(9):4808-16

Mora-Zamorano, F.X., Svoboda, K.R., Carvan, M.J. (2016) The Nicotine-Evoked Locomotor Response: A Behavioral Paradigm for Toxicity Screening in Zebrafish (Danio rerio) Embryos and Eleutheroembryos Exposed to Methylmercury. PLoS One. 11:e0154570

Wilson, C.A., High, S.K., McCluskey, B.M., Amores, A., Yan, Y.L., Titus, T.A., Anderson, J.L., Batzel, P., Carvan, M.J., Schartl, M., Postlethwait, J.H. (2014) Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains. Genetics. 198(3):1291-308

Tomasiewicz, H.G., Hesselbach, R., Carvan, M.J., Goldberg, B., Berg, C.A., Petering, D.H. (2014) Zebrafish as a Model System for Environmental Health Studies in the Grade 9-12 Classroom. Zebrafish. 11(4):384-95

Liu, Q., Spitsbergen, J.M., Cariou, R., Huang, C.Y., Jiang, N., Goetz, G., Hutz, R.J., Tonellato, P.J., Carvan, M.J. (2014) Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. PLoS One. 9:e100910

Flentke, G.R., Klingler, R.H., Tanguay, R.L., Carvan, M.J., and Smith, S.M. (2014) An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcoholism, clinical and experimental research. 38(5):1255-65

Liu, Q., Basu, N., Goetz, G., Jiang, N., Hutz, R.J., Tonellato, P.J., and Carvan, M.J. (2013) Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology (London, England). 22(4):740-51

Xu, X., Weber, D., Carvan, M.J., Coppens, R., Lamb, C., Goetz, S., and Schaefer, L.A. (2012) Comparison of neurobehavioral effects of methylmercury exposure in older and younger adult zebrafish (Danio rerio). Neurotoxicology. 33(5):1212-1218

Frost, F., Craun, G., Brown, K.G., Wartenberg, D., Scott, C.S., Ladero, J.M., Nebert, D.W., Stuart, G.W., Solis, W.A., and Carvan, M.J. III (2011) EHP 110-1, 2002: Correspondence. Environmental health perspectives. 110(1):2-15

Smith, L.E., Carvan, M.J. 3rd, Dellinger, J.A., Ghorai, J.K., White, D.B., Williams, F.E., and Weber, D.N. (2010) Developmental selenomethionine and methylmercury exposures affect zebrafish learning. Neurotoxicology and teratology. 32(2):246-255

Carvan III, M.J., Incardona, J.P., and Rise, M.L. (2008) Meeting the Challenges of Aquatic Vertebrate Ecotoxicology. Bioscience. 58(11):1015-1025

Weber, D.N., Connaughton, V.P., Dellinger, J.A., Klemer, D., Udvadia, A., and Carvan, MJ 3rd. (2008) Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiology & behavior. 93(1-2):250-260

Aleström, P., Begemann, G., Carvan, M.J. 3rd, Cheng, K.C., Crosier, K., Crosier, P., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G., Mione, M., Neely, M.N., Neuhauss, S., and Trede, N.S. (2008) Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24

Heiden, T.C., Struble, C.A., Rise, M.L., Hessner, M.J., Hutz, R.J., and Carvan, M.J. 3rd. (2008) Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD-induced endocrine disruption and reproductive toxicity. Reproductive toxicology (Elmsford, N.Y.). 25(1):47-57

Pullela, P.K., Chiku, T., Carvan, M.J. 3rd, and Sem, D.S. (2006) Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes. Analytical biochemistry. 352(2):265-273

Arenzana, F.J., Carvan, M.J. 3rd, Aijon, J., Sanchez-Gonzalez, R., Arevalo, R., and Porteros, A. (2006) Teratogenic effects of ethanol exposure on zebrafish visual system development. Neurotoxicology and teratology. 28(3):342-348

King Heiden, T., Carvan, M.J., 3rd, and Hutz, R.J. (2006) Inhibition of Follicular Development, Vitellogenesis and Serum 17{beta} Estradiol Concentrations in Zebrafish Following Chronic, Sublethal Dietary Exposure to 2,3,7,8,-Tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 90(2):490-499

Hutz, R.J., Carvan, M.J., Baldridge, M.G., Conley, L.K., and Heiden, T.K. (2006) Environmental toxicants and effects on female reproductive function. Trends in reproductive biology. 2:1-11

Heiden, T.K., Hutz, R.J., and Carvan, M.J. 3rd. (2005) Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8,-tetrachlorodibenzo-p-dioxin: impacts on reproductive success of zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 87(2):497-507

Carvan, M.J. III, Loucks, E., Weber, D.N., and Williams, F.E. (2004) Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicology and teratology. 26(6):757-768

Loucks, E., and Carvan, M.J. III (2004) Strain-dependent effects of developmental ethanol exposure in zebrafish. Neurotoxicology and teratology. 26(6):745-755

Postlethwait, J., Ruotti, V., Carvan, M.J., and Tonellato, P.J. (2004) Automated analysis of conserved syntenies for the zebrafish genome. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:255-271

Nebert, D.W., Stuart, G.W., Solis, W.A., and Carvan, M.J. III (2002) Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution. Environmental health perspectives. 110(1):A15

Dasmahapatra, A.K., Doucet, H.L., Bhattacharyya, C., Carvan III, M.J. (2001) Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 286(5):1082-1086

Carvan III, M.J., Sonntag, D.M., Cmar, C.B., Cook, R.S., Curran, M.A., and Miller, G.L. (2001) Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. The Science of the total environment. 274(1-3):183-196

Dalton, T.P., Solis, W.A., Nebert, D.W., and Carvan, M.J., III (2000) Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 126(3):325-335

Carvan III, M.J., Solis, W.A., Gedamu, L., and Nebert, D.W. (2000) Activation of transcription factors in zebrafish cell cultures by environmental pollutants. Archives of biochemistry and biophysics. 376(2):320-327

Carvan III, M.J., Dalton, T.P., Stuart, G.W., and Nebert, D.W. (2000) Transgenic zebrafish as sentinels for aquatic pollution. Annals of the New York Academy of Sciences. 919:133-147

NON-ZEBRAFISH PUBLICATIONS
Nebert, D.W., T.P. Dalton, G.W. Stuart and M.J. Carvan III. 2000. 'Gene-swap knock-in' cassette in mice to study allelic differences in human genes. Annals of the New York Academy of Science, 919:148-170.

Carvan, M.J.,III, L.V. Ponomareva, W.A. Solis, R.S. Matlib, A. Puga, and D.W. Nebert. 1999. Trout CYP1A3 gene: recognition of fish DNA motifs by mouse regulatory proteins. Marine Biotechnology 1:155-166.

Nebert, D.W. and M.J. Carvan III. 1997. Ecogenetics: From Ecology to Health. Toxicology and Industrial Health 13:1-31.

Flood, L.P., M.J. Carvan III, L. Yeager, and D. L. Busbee. 1996. Reduction in hepatic microsomal P-450 and related catalytic activity in farm-raised red drum. Journal of Aquatic Animal Health 8:13-21.

Alterman, M.A., M.J. Carvan and D.L. Busbee. 1995. Dose-dependent induction of the microsomal monooxygenase system by phenobarbital and 3-methylcholanthrene in ad libitum and calorie restricted female rats. Xenobiotica 25:17-26.

Carvan, M.J.,III, L.P. Flood, B. D. Campbell, and D.L. Busbee. 1995. Effects of benzo(a)pyrene on fetal dolphin kidney epithelial cells: Inhibition of proliferation and initiation of DNA damage. Chemosphere 30:187-198.

Alterman, M.A., M.J. Carvan and D.L. Busbee. 1994. Ethoxyresorufin and pentoxyresorufin O-dealkylation by hepatic microsomes from female Fisher 344 rats: effects of age and diet. Mechanisms of Aging and Development 77:1-11.

Carvan, M.J.,III, M. Santostefano, S. Safe and D.L. Busbee. 1994. Characterization of a bottlenose dolphin (Tursiops truncatus) kidney epithelial cell line. Marine Mammal Science 10:52-69.

Alterman, M.A., V.K. Srivastava, M.J. Carvan, J. Leakey, R. Hart and D.L. Busbee. 1993. Effects of aging and long term caloric restriction on hepatic microsomal monooxygenases in female Fisher 344 rats: alterations in the basal cytochrome P-450 catalytic activities. AGE, J. American Aging Association 16:1-8.