ZFIN ID: ZDB-LAB-200814-1 |
Rastegar Lab
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GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS
Our research is dedicated to investigating the molecular mechanisms that govern neurogenesis in both zebrafish embryos and the adult central nervous system (CNS). Specifically, we have a keen interest in understanding the intricate role of transcriptional regulators (TRs) and their corresponding cis-regulatory elements (CREs) in dictating the precise expression patterns of TRs within the embryonic spinal cord and adult telencephalon. Transcriptional regulators play pivotal roles in orchestrating gene expression patterns during neurogenesis. These regulators bind to specific regions of DNA called cis-regulatory elements, located within the regulatory regions of genes. By interacting with these cis-regulatory elements, TRs can either enhance or suppress gene expression, thereby determining when and where specific TRs are active during neurodevelopment. Our research endeavors to decipher the complex network of TRs and CREs that intricately regulate neurogenesis in zebrafish embryos and the adult CNS. Employing a wide range of molecular biology techniques, including advanced gene editing technologies such as CRISPR/Cas9, transgenic reporter assays, and high-throughput sequencing methods, we aim to identify and characterize the key TRs and CREs responsible for controlling neurogenesis.
LAB MEMBERS
Chen, Fushun Graduate Student | Chen, Jincan Graduate Student | Cucun, Gokhan Graduate Student |
Köhler, Melina Graduate Student | Pfitsch, Sabrina Graduate Student | Beil, Tanja Technical Staff |
Schröck, Anne Technical Staff |
ZEBRAFISH PUBLICATIONS OF LAB MEMBERS