ZFIN ID: ZDB-LAB-180718-1
van Ham Lab
PI/Director: van Ham, Tjakko
Contact Person: van Ham, Tjakko
Email: t.vanham@erasmusmc.nl
URL: http://www.erasmusmc.nl/klinische_genetica/research/introduction/van_Ham/?lang=en
Address: Department of Clinical Genetics Erasmus University Medical Center Rotterdam Wytemaweg 80, 3015 CN Rotterdam, The Netherlands
Country: Netherlands
Phone: +31 6 14737671
Fax:
Line Designation: re


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 12 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Sanderson, Leslie Post-Doc Kuil, Laura Graduate Student van der Linde, Herma Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Kakiailatu, N.J.M., Kuil, L.E., Bindels, E., Zink, J.T.M., Vermeulen, M., Melotte, V., Alves, M.M. (2023) Gut Isolation from Zebrafish Larvae for Single-cell RNA Sequencing. Journal of visualized experiments : JoVE. (201):
Ruijmbeek, C.W., Housley, F., Idrees, H., Housley, M.P., Pestel, J., Keller, L., Lai, J.K.H., van der Linde, H.C., Willemsen, R., Piesker, J., Al-Hassnan, Z.N., Almesned, A., Dalinghaus, M., van den Bersselaar, L.M., van Slegtenhorst, M.A., Tessadori, F., Bakkers, J., van Ham, T.J., Stainier, D.Y., Verhagen, J.M., Reischauer, S. (2023) Bi-allelic variants in FLII cause pediatric cardiomyopathy by disrupting cardiomyocyte cell adhesion and myofibril organization. JCI insight. 8(17):
Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
Deng, R., Medico-Salsench, E., Nikoncuk, A., Ramakrishnan, R., Lanko, K., Kühn, N.A., van der Linde, H.C., Lor-Zade, S., Albuainain, F., Shi, Y., Yousefi, S., Capo, I., van den Herik, E.M., van Slegtenhorst, M., van Minkelen, R., Geeven, G., Mulder, M.T., Ruijter, G.J.G., Lütjohann, D., Jacobs, E.H., Houlden, H., Pagnamenta, A.T., Metcalfe, K., Jackson, A., Banka, S., De Simone, L., Schwaede, A., Kuntz, N., Palculict, T.B., Abbas, S., Umair, M., AlMuhaizea, M., Colak, D., AlQudairy, H., Alsagob, M., Pereira, C., Trunzo, R., Karageorgou, V., Bertoli-Avella, A.M., Bauer, P., Bouman, A., Hoefsloot, L.H., van Ham, T.J., Issa, M., Zaki, M.S., Gleeson, J.G., Willemsen, R., Kaya, N., Arold, S.T., Maroofian, R., Sanderson, L.E., Barakat, T.S. (2023) AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathologica. 146(2):353-368
Djannatian, M., Radha, S., Weikert, U., Safaiyan, S., Wrede, C., Deichsel, C., Kislinger, G., Rhomberg, A., Ruhwedel, T., Campbell, D.S., van Ham, T., Schmid, B., Hegermann, J., Möbius, W., Schifferer, M., Simons, M. (2023) Myelination generates aberrant ultrastructure that is resolved by microglia. The Journal of cell biology. 222(3):
Zada, A., Kuil, L.E., de Graaf, B.M., Kakiailatu, N., Windster, J.D., Brooks, A.S., van Slegtenhorst, M., de Koning, B., Wijnen, R.M.H., Melotte, V., Hofstra, R.M.W., Brosens, E., Alves, M.M. (2022) TFAP2B Haploinsufficiency Impacts Gastrointestinal Function and Leads to Pediatric Intestinal Pseudo-obstruction. Frontiers in cell and developmental biology. 10:901824
Berdowski, W.M., van der Linde, H.C., Breur, M., Oosterhof, N., Beerepoot, S., Sanderson, L., Wijnands, L.I., de Jong, P., Tsai-Meu-Chong, E., de Valk, W., de Witte, M., van IJcken, W.F.J., Demmers, J., van der Knaap, M.S., Bugiani, M., Wolf, N.I., van Ham, T.J. (2022) Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy. Acta Neuropathologica. 144(2):211-239
Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
Riemslagh, F.W., Verhagen, R.F.M., van der Toorn, E.C., Smits, D.J., Quint, W.H., van der Linde, H.C., van Ham, T.J., Willemsen, R. (2021) Reduction of oxidative stress suppresses poly-GR mediated toxicity in zebrafish embryos. Disease models & mechanisms. 14(11):
Yousefi, S., Deng, R., Lanko, K., Salsench, E.M., Nikoncuk, A., van der Linde, H.C., Perenthaler, E., van Ham, T.J., Mulugeta, E., Barakat, T.S. (2021) Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance. Genome Medicine. 13:162
Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698
Berdowski, W.M., Sanderson, L.E., van Ham, T.J. (2021) The multicellular interplay of microglia in health and disease: lessons from leukodystrophy. Disease models & mechanisms. 14(8)
Sofou, K., Meier, K., Sanderson, L.E., Kaminski, D., Montoliu-Gaya, L., Samuelsson, E., Blomqvist, M., Agholme, L., Gärtner, J., Mühlhausen, C., Darin, N., Barakat, T.S., Schlotawa, L., van Ham, T., Asin Cayuela, J., Sterky, F.H. (2021) Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease. EMBO Molecular Medicine. 13(5):e13376
Sanderson, L.E., Lanko, K., Alsagob, M., Almass, R., Al-Ahmadi, N., Najafi, M., Al-Muhaizea, M.A., Alzaidan, H., AlDhalaan, H., Perenthaler, E., van der Linde, H.C., Nikoncuk, A., Kühn, N.A., Antony, D., Owaidah, T.M., Raskin, S., Vieira, L.G.D.R., Mombach, R., Ahangari, N., Silveira, T.R.D., Ameziane, N., Rolfs, A., Alharbi, A., Sabbagh, R.M., AlAhmadi, K., Alawam, B., Ghebeh, H., AlHargan, A., Albader, A.A., Binhumaid, F.S., Goljan, E., Monies, D., Mustafa, O.M., Aldosary, M., AlBakheet, A., Alyounes, B., Almutairi, F., Al-Odaib, A., Aksoy, D.B., Basak, A.N., Palvadeau, R., Trabzuni, D., Rosenfeld, J.A., Karimiani, E.G., Meyer, B.F., Karakas, B., Al-Mohanna, F., Arold, S.T., Colak, D., Maroofian, R., Houlden, H., Bertoli-Avella, A.M., Schmidts, M., Barakat, T.S., van Ham, T.J., Kaya, N. (2021) Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking. Brain : a journal of neurology. 144(3):769-780
Van Dyck, A., Bollaerts, I., Beckers, A., Vanhunsel, S., Glorian, N., van Houcke, J., van Ham, T.J., De Groef, L., Andries, L., Moons, L. (2021) Müller glia-myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish. Glia. 69(6):1444-1463
Kuil, L.E., Chauhan, R.K., Cheng, W.W., Hofstra, R.M.W., Alves, M.M. (2021) Zebrafish: A Model Organism for Studying Enteric Nervous System Development and Disease. Frontiers in cell and developmental biology. 8:629073
Cunha, M.I., Su, M., Cantuti-Castelvetri, L., Müller, S.A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T.J., Schmid, B., Lichtenthaler, S.F., Stadelmann, C., Simons, M. (2020) Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. The Journal of experimental medicine. 217(5):
Perenthaler, E., Nikoncuk, A., Yousefi, S., Berdowski, W.M., Alsagob, M., Capo, I., van der Linde, H.C., van den Berg, P., Jacobs, E.H., Putar, D., Ghazvini, M., Aronica, E., van IJcken, W.F.J., de Valk, W.G., Medici-van den Herik, E., van Slegtenhorst, M., Brick, L., Kozenko, M., Kohler, J.N., Bernstein, J.A., Monaghan, K.G., Begtrup, A., Torene, R., Al Futaisi, A., Al Murshedi, F., Mani, R., Al Azri, F., Kamsteeg, E.J., Mojarrad, M., Eslahi, A., Khazaei, Z., Darmiyan, F.M., Doosti, M., Karimiani, E.G., Vandrovcova, J., Zafar, F., Rana, N., Kandaswamy, K.K., Hertecant, J., Bauer, P., AlMuhaizea, M.A., Salih, M.A., Aldosary, M., Almass, R., Al-Quait, L., Qubbaj, W., Coskun, S., Alahmadi, K.O., Hamad, M.H.A., Alwadaee, S., Awartani, K., Dababo, A.M., Almohanna, F., Colak, D., Dehghani, M., Mehrjardi, M.Y.V., Gunel, M., Ercan-Sencicek, A.G., Passi, G.R., Cheema, H.A., Efthymiou, S., Houlden, H., Bertoli-Avella, A.M., Brooks, A.S., Retterer, K., Maroofian, R., Kaya, N., van Ham, T.J., Barakat, T.S. (2019) Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Acta Neuropathologica. 139(3):415-442
Vaz, R.L., Sousa, S., Chapela, D., van der Linde, H.C., Willemsen, R., Correia, A.D., Outeiro, T.F., Afonso, N.D. (2019) Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model. Pharmacology, biochemistry, and behavior. 189:172828
Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Kuil, L.E., van Ham, T.J., Zagury, J.F., Sieger, D. (2019) Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Glia. 68(2):298-315
Verhagen, J.M.A., van den Born, M., van der Linde, H.C., Nikkels, P.G.J., Verdijk, R.M., Kivlen, M.H., van Unen, L.M.A., Baas, A.F., Ter Heide, H., van Osch-Gevers, L., Hoogeveen-Westerveld, M., Herkert, J.C., Bertoli-Avella, A.M., van Slegtenhorst, M.A., Wessels, M.W., Verheijen, F.W., Hassel, D., Hofstra, R.M.W., Hegde, R.S., van Hasselt, P.M., van Ham, T.J., van de Laar, I.M.B.H. (2019) Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. Circulation. Genomic and precision medicine. 12(9):397-406
Kuil, L.E., López Martí, A., Carreras Mascaro, A., van den Bosch, J.C., van den Berg, P., van der Linde, H.C., Schoonderwoerd, K., Ruijter, G.J.G., van Ham, T.J. (2019) Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development. Glia. 67(9):1705-1718
Oosterhof, N., Chang, I.J., Karimiani, E.G., Kuil, L.E., Jensen, D.M., Daza, R., Young, E., Astle, L., van der Linde, H.C., Shivaram, G.M., Demmers, J., Latimer, C.S., Keene, C.D., Loter, E., Maroofian, R., van Ham, T.J., Hevner, R.F., Bennett, J.T. (2019) Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia. American journal of human genetics. 104(5):936-947
Kuil, L.E., Oosterhof, N., Geurts, S.N., van der Linde, H.C., Meijering, E., van Ham, T.J. (2019) Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Disease models & mechanisms. 12(3):
Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670
Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
Gao, Y., de Wit, M., Struys, E.A., van der Linde, H.C.Z., Salomons, G.S., Lamfers, M.L.M., Willemsen, R., Sillevis Smitt, P.A.E., French, P.J. (2018) IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis. PLoS One. 13:e0199737
Gui, H., Schriemer, D., Cheng, W.W., Chauhan, R.K., Antiňolo, G., Berrios, C., Bleda, M., Brooks, A.S., Brouwer, R.W., Burns, A.J., Cherny, S.S., Dopazo, J., Eggen, B.J., Griseri, P., Jalloh, B., Le, T.L., Lui, V.C., Luzón-Toro, B., Matera, I., Ngan, E.S., Pelet, A., Ruiz-Ferrer, M., Sham, P.C., Shepherd, I.T., So, M.T., Sribudiani, Y., Tang, C.S., van den Hout, M.C., van der Linde, H.C., van Ham, T.J., van IJcken, W.F., Verheij, J.B., Amiel, J., Borrego, S., Ceccherini, I., Chakravarti, A., Lyonnet, S., Tam, P.K., Garcia-Barceló, M.M., Hofstra, R.M. (2017) Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome biology. 18:48
Oosterhof, N., Holtman, I.R., Kuil, L.E., van der Linde, H.C., Boddeke, E.W., Eggen, B.J., van Ham, T.J. (2017) Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 65(1):138-149
Oosterhof, N., Kuil, L.E., van Ham, T.J. (2017) Microglial Activation by Genetically Targeted Conditional Neuronal Ablation in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 1559:377-390
Kuipers, J., Kalicharan, R.D., Wolters, A.H., van Ham, T.J., Giepmans, B.N. (2016) Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain. Journal of visualized experiments : JoVE. (111)
Oosterhof, N., Boddeke, E., van Ham, T.J. (2015) Immune cell dynamics in the CNS: Learning from the zebrafish. Glia. 63(5):719-35
van Ham, T.J., Brady, C.A., Kalicharan, R.D., Oosterhof, N., Kuipers, J., Veenstra-Algra, A., Sjollema, K.A., Peterson, R.T., Kampinga, H.H., Giepmans, B.N. (2014) Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Disease models & mechanisms. 7:857-869
Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
van Ham, T.J., Kokel, D., and Peterson, R.T. (2012) Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment. Current biology : CB. 22(9):830-836
van Ham, T.J., Mapes, J., Kokel, D., and Peterson, R.T. (2010) Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(11):4336-4342