ZFIN ID: ZDB-LAB-161004-2
Qiang Wang Lab
PI/Director: Wang, Qiang
Contact Person: Wang, Qiang
Email: qiangwang@scut.edu.cn
URL: http://sourcedb.cas.cn/sourcedb_ioz_cas/yw/scs/pi/200907/t20090716_2088383.html
Address: Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, China
Country: China
Phone: 86-20-39380943
Line Designation: szy

Show all 29 genomic features

The basic body plan of vertebrate embryos is established during embryo morphogenesis. How a relatively uniform embryo becomes asymmetric at the early developmental stages? This asymmetry consists of two aspects, the initial cell fate decision and the embryonic body patterning that establishes the dorsal-ventral, anterior-posterior, and left-right axes. Understanding the underlying molecular genetic mechanisms of these morphogenetic processes is one of the central goals of developmental biology. The function of genes and signal pathways, such as TGF-β, BMP and Wnt, are being studied in zebrafish embryos and mammalian cell lines using genetic, biochemical and molecular approaches. Research progresses on the great mysteries during embryo morphogenesis will help us to get a better understanding of how a fertilized egg gives rise to a live baby.


Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
Sun, W., Wang, M., Zhao, J., Zhao, S., Zhu, W., Wu, X., Li, F., Liu, W., Wang, Z., Gao, M., Zhang, Y., Xu, J., Zhang, M., Wang, Q., Wen, Z., Shen, J., Zhang, W., Huang, Z. (2023) Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. Nature communications. 14:53515351
Li, Y., Ning, G., Kang, B., Zhu, J., Wang, X.Y., Wang, Q., Cai, T. (2022) A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish. Human molecular genetics. 32(5):764-772
Yang, S., Ning, G., Hou, Y., Cao, Y., Xu, J., Wu, J., Zhang, T., Wang, Q. (2022) Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. iScience. 25:104495
Yan, H., Yang, S., Hou, Y., Ali, S., Escobar, A., Gao, K., Duan, R., Kubisiak, T., Wang, J., Zhang, Y., Xiao, J., Jiang, Y., Zhang, T., Wu, Y., Burmeister, M., Wang, Q., Cuajungco, M.P., Wang, J. (2022) Functional Study of TMEM163 Gene Variants Associated with Hypomyelination Leukodystrophy. Cells. 11(8):
Mao, A., Zhang, M., Li, L., Liu, J., Ning, G., Cao, Y., Wang, Q. (2020) Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. Development (Cambridge, England). 148(2):
Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
Yan, Y., Ning, G., Li, L., Liu, J., Yang, S., Cao, Y., Wang, Q. (2019) The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning. Science advances. 5:eaau6455
Mao, A., Zhang, M., Liu, J., Cao, Y., Wang, Q. (2019) PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis. Journal of genetics and genomics = Yi chuan xue bao. 46(12):551-559
Liu, J., Zhu, C., Ning, G., Yang, L., Cao, Y., Huang, S., Wang, Q. (2019) Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking. PLoS Biology. 17:e3000203
Sun, H.J., Zhang, J.Y., Wang, Q., Zhu, E., Chen, W., Lin, H., Chen, J., Hong, H. (2019) Environmentally relevant concentrations of arsenite induces developmental toxicity and oxidative responses in the early life stage of zebrafish. Environmental pollution (Barking, Essex : 1987). 254:113022
Jiang, J., Wu, S., Lv, L., Liu, X., Chen, L., Zhao, X., Wang, Q. (2019) Mitochondrial dysfunction, apoptosis and transcriptomic alterations induced by four strobilurins in zebrafish (Danio rerio) early life stages. Environmental pollution (Barking, Essex : 1987). 253:722-730
Li, L., Ning, G., Yang, S., Yan, Y., Cao, Y., Wang, Q. (2019) BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLoS Genetics. 15:e1007996
Li, L., Mao, A., Wang, P., Ning, G., Cao, Y., Wang, Q. (2018) Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation.. Biology Open. 7(12):
Wang, Y., Dai, D., Yu, Y., Yang, G., Shen, W., Wang, Q., Weng, H., Zhao, X. (2018) Evaluation of joint effects of cyprodinil and kresoxim-methyl on zebrafish, Danio rerio. Journal of hazardous materials. 352:80-91
Wang, Y., Wu, S., Chen, J., Zhang, C., Xu, Z., Li, G., Cai, L., Shen, W., Wang, Q. (2017) Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 192:14-23
Wei, S., Ning, G., Li, L., Yan, Y., Yang, S., Cao, Y., Wang, Q. (2017) A GEF activity-independent function for nuclear Net1 in Nodal/Smad2 signal transduction and mesendoderm formation. Journal of Cell Science. 130(18):3072-3082
Wang, Y., Lv, L., Yu, Y., Yang, G., Xu, Z., Wang, Q., Cai, L. (2017) Single and joint toxic effects of five selected pesticides on the early life stages of zebrafish (Denio rerio). Chemosphere. 170:61-67
Wang, Y., Yang, G., Dai, D., Xu, Z., Cai, L., Wang, Q., Yu, Y. (2017) Individual and mixture effects of five agricultural pesticides on zebrafish (Danio rerio) larvae. Environmental science and pollution research international. 24(5):4528-4536
Wei, S., Dai, M., Liu, Z., Ma, Y., Shang, H., Cao, Y., Wang, Q. (2017) The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Research. 27(2):202-225
Guo, D., Wang, Y., Qian, Y., Chen, C., Jiao, B., Cai, L., Wang, Q. (2017) Joint acute and endocrine disruptive toxicities of malathion, cypermethrin and prochloraz to embryo-larval zebrafish, Danio rerio. Chemosphere. 166:63-71
Liu, H., Li, X., Ning, G., Zhu, S., Ma, X., Liu, X., Liu, C., Huang, M., Schmitt, I., Wüllner, U., Niu, Y., Guo, C., Wang, Q., Tang, T.S. (2016) The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLoS Biology. 14:e2000733
Liu, Z., Ning, G., Xu, R., Cao, Y., Meng, A., Wang, Q. (2016) Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nature communications. 7:12603
Wei, S., Shang, H., Cao, Y., Wang, Q. (2016) The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/β-catenin activity during zebrafish dorsoventral axial patterning. Journal of genetics and genomics = Yi chuan xue bao. 43(7):431-8
Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24
Ma, H., Lin, Y., Zhao, Z.A., Lu, X., Yu, Y., Zhang, X., Wang, Q., Li, L. (2016) MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. The Journal of biological chemistry. 291:12126-35
Jiang, J., Chen, Y., Yu, R., Zhao, X., Wang, Q., Cai, L. (2016) Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Environmental Toxicology and Pharmacology. 42:125-134
Liu, X., Wang, Q., Meng, A. (2016) Detection of Smad Signaling in Zebrafish Embryos. Methods in molecular biology (Clifton, N.J.). 1344:275-286
Gao, M., Yan, H., Yin, R.H., Wang, Q., Zhan, Y.Q., Yu, M., Ge, C.H., Li, C.Y., Wang, X.H., Ge, Z.Q., Yang, X.M. (2015) Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis. Biochemical and Biophysical Research Communications. 463(3):466-71
Ma, Y., Liu, X., Liu, Z., Wei, S., Shang, H., Xue, Y., Cao, Y., Meng, A., Wang, Q. (2015) The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:8493-506
Huang, Y.F., Zhou, X., Zhou, R., Zhang, H., Kang, K.B., Zhao, M., Peng, Y., Wang, Q., Zhang, H.L., Qiu, W.Y. (2014) One-pot synthesis of highly luminescent carbon quantum dots and their nontoxic ingestion by zebrafish for in vivo imaging. Chemistry (Weinheim an der Bergstrasse, Germany). 20:5640-8
Liu, X., Ma, Y., Zhang, C., Wei, S., Cao, Y., and Wang, Q. (2013) Nodal Promotes mir206 Expression to Control Convergence and Extension Movements During Zebrafish Gastrulation. Journal of genetics and genomics = Yi chuan xue bao. 40(10):515-521
Xu, R.R., Zhang, C.W., Cao, Y., and Wang, Q. (2013) mir122 deficiency inhibits differentiation of zebrafish hepatoblast into hepatocyte. Yi chuan = Hereditas. 35(4):488-494
Ning, G., Liu, X., Dai, M., Meng, A., and Wang, Q. (2013) MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Developmental Cell. 24(3):283-295
Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nature communications. 4:1728
Liu, Z.T., Wei, S., and Wang, Q. (2012) The Nodal regulated dusp4 inhibits mesendoderm formation during zebrafish gastrulation. Yi chuan = Hereditas. 34(9):1153-1158
Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32