ZFIN Person: Wang, Qiang

ZFIN ID: ZDB-PERS-140417-1

ZFIN ID: ZDB-PERS-140417-1

Wang, Qiang

Email:	qiangwang@ioz.ac.cn
URL:	http://sourcedb.cas.cn/sourcedb_ioz_cas/yw/scs/pi/200907/t20090716_2088383.html
Affiliation:	Qiang Wang Lab
Address:	State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS), 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Country:	China
Phone:	86-10-64807895
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Dr. Qiang Wang
Born: November 1, 1975 in China.
professor in the Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China (100101),
Tel: 86-10-64807895 (lab)
Fax: 86-10-64807895
E-mail: qiangwang@ioz.ac.cn

Dr. Wang is professor at State Key Laboratory of Biomembrane and Membrane Biotechnology in the Institute of Zoology, Chinese Academy of Sciences, and he is a recipient of National Science Fund for Excellent Young Scholars. Dr. Wang mainly works on signal transduction regulation, and has made significant progress in elucidating the regulation mechanism of TGF-β superfamily signaling during early embryo development and tissue formation. The related papers were published on the famous international academic journals such as Developmental Cell, Blood, Molecular and Cellular Biology, J Biol.Chem. etc.

EDUCATION
Postdoctoral fellowship in Molecular Cell Biology Lab, Departement of Biological Sciences and Biotechnology, Tsinghua Unversity, Beijing, P. R. China, July, 2004~2008.

Ph.D. in Lab of Developmental Immunology, College of Life Science, Shandong University, Shandong province, P. R. China, 1999～2004 (Major thesis research done in Pathology Department, Peking Univeristy Health Science Centre, November, 2001~ March, 2004).

B.S. in Biological Science, College of Life Science, Shandong University, Shandong province, Beijing, P. R. China, 1999.

WORK EXPERIENCE
Associate professor in the Institute of Zoology, Chinese Academy of Sciences, 2008~2012, Beijing, P. R. China
Professor in the Institute of Zoology, Chinese Academy of Sciences, 2013~present, Beijing, P. R. China

MAIN RESEARCH FIELDS:
We are particularly interested in the roles of TGF-β/Nodal and Wnt signaling pathways in mesoderm induction and dorsovental patterning of vertebrate embryos. Genes mediating Nodal and Wnt signaling in zebrafish embryos are being studied using genetic, biochemical and molecular approaches. We also aim to understand the functional importance of microRNAs in early development of zebrafish embryos.

PUBLICATIONS

Yang, S., Ning, G., Hou, Y., Cao, Y., Xu, J., Wu, J., Zhang, T., Wang, Q. (2022) Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. iScience. 25:104495

Yan, H., Yang, S., Hou, Y., Ali, S., Escobar, A., Gao, K., Duan, R., Kubisiak, T., Wang, J., Zhang, Y., Xiao, J., Jiang, Y., Zhang, T., Wu, Y., Burmeister, M., Wang, Q., Cuajungco, M.P., Wang, J. (2022) Functional Study of TMEM163 Gene Variants Associated with Hypomyelination Leukodystrophy. Cells. 11(8):

Mao, A., Zhang, M., Li, L., Liu, J., Ning, G., Cao, Y., Wang, Q. (2020) Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification. Development (Cambridge, England). 148(2):

Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844

Yan, Y., Ning, G., Li, L., Liu, J., Yang, S., Cao, Y., Wang, Q. (2019) The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning. Science advances. 5:eaau6455

Mao, A., Zhang, M., Liu, J., Cao, Y., Wang, Q. (2019) PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis. Journal of genetics and genomics = Yi chuan xue bao. 46(12):551-559

Liu, J., Zhu, C., Ning, G., Yang, L., Cao, Y., Huang, S., Wang, Q. (2019) Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking. PLoS Biology. 17:e3000203

Sun, H.J., Zhang, J.Y., Wang, Q., Zhu, E., Chen, W., Lin, H., Chen, J., Hong, H. (2019) Environmentally relevant concentrations of arsenite induces developmental toxicity and oxidative responses in the early life stage of zebrafish. Environmental pollution (Barking, Essex : 1987). 254:113022

Jiang, J., Wu, S., Lv, L., Liu, X., Chen, L., Zhao, X., Wang, Q. (2019) Mitochondrial dysfunction, apoptosis and transcriptomic alterations induced by four strobilurins in zebrafish (Danio rerio) early life stages. Environmental pollution (Barking, Essex : 1987). 253:722-730

Li, L., Ning, G., Yang, S., Yan, Y., Cao, Y., Wang, Q. (2019) BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLoS Genetics. 15:e1007996

Li, L., Mao, A., Wang, P., Ning, G., Cao, Y., Wang, Q. (2018) Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation.. Biology Open. 7(12):

Wang, Y., Dai, D., Yu, Y., Yang, G., Shen, W., Wang, Q., Weng, H., Zhao, X. (2018) Evaluation of joint effects of cyprodinil and kresoxim-methyl on zebrafish, Danio rerio. Journal of hazardous materials. 352:80-91

Wang, Y., Wu, S., Chen, J., Zhang, C., Xu, Z., Li, G., Cai, L., Shen, W., Wang, Q. (2017) Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 192:14-23

Wei, S., Ning, G., Li, L., Yan, Y., Yang, S., Cao, Y., Wang, Q. (2017) A GEF activity-independent function for nuclear Net1 in Nodal/Smad2 signal transduction and mesendoderm formation. Journal of Cell Science. 130(18):3072-3082

Wang, Y., Lv, L., Yu, Y., Yang, G., Xu, Z., Wang, Q., Cai, L. (2017) Single and joint toxic effects of five selected pesticides on the early life stages of zebrafish (Denio rerio). Chemosphere. 170:61-67

Wang, Y., Yang, G., Dai, D., Xu, Z., Cai, L., Wang, Q., Yu, Y. (2017) Individual and mixture effects of five agricultural pesticides on zebrafish (Danio rerio) larvae. Environmental science and pollution research international. 24(5):4528-4536

Wei, S., Dai, M., Liu, Z., Ma, Y., Shang, H., Cao, Y., Wang, Q. (2017) The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Research. 27(2):202-225

Guo, D., Wang, Y., Qian, Y., Chen, C., Jiao, B., Cai, L., Wang, Q. (2017) Joint acute and endocrine disruptive toxicities of malathion, cypermethrin and prochloraz to embryo-larval zebrafish, Danio rerio. Chemosphere. 166:63-71

Liu, H., Li, X., Ning, G., Zhu, S., Ma, X., Liu, X., Liu, C., Huang, M., Schmitt, I., Wüllner, U., Niu, Y., Guo, C., Wang, Q., Tang, T.S. (2016) The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLoS Biology. 14:e2000733

Liu, Z., Ning, G., Xu, R., Cao, Y., Meng, A., Wang, Q. (2016) Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nature communications. 7:12603

Wei, S., Shang, H., Cao, Y., Wang, Q. (2016) The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/β-catenin activity during zebrafish dorsoventral axial patterning. Journal of genetics and genomics = Yi chuan xue bao. 43(7):431-8

Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24

Ma, H., Lin, Y., Zhao, Z.A., Lu, X., Yu, Y., Zhang, X., Wang, Q., Li, L. (2016) MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. The Journal of biological chemistry. 291:12126-35

Jiang, J., Chen, Y., Yu, R., Zhao, X., Wang, Q., Cai, L. (2016) Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Environmental Toxicology and Pharmacology. 42:125-134

Liu, X., Wang, Q., Meng, A. (2016) Detection of Smad Signaling in Zebrafish Embryos. Methods in molecular biology (Clifton, N.J.). 1344:275-286

Gao, M., Yan, H., Yin, R.H., Wang, Q., Zhan, Y.Q., Yu, M., Ge, C.H., Li, C.Y., Wang, X.H., Ge, Z.Q., Yang, X.M. (2015) Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis. Biochemical and Biophysical Research Communications. 463(3):466-71

Ma, Y., Liu, X., Liu, Z., Wei, S., Shang, H., Xue, Y., Cao, Y., Meng, A., Wang, Q. (2015) The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:8493-506

Huang, Y.F., Zhou, X., Zhou, R., Zhang, H., Kang, K.B., Zhao, M., Peng, Y., Wang, Q., Zhang, H.L., Qiu, W.Y. (2014) One-pot synthesis of highly luminescent carbon quantum dots and their nontoxic ingestion by zebrafish for in vivo imaging. Chemistry (Weinheim an der Bergstrasse, Germany). 20:5640-8

Liu, X., Ma, Y., Zhang, C., Wei, S., Cao, Y., and Wang, Q. (2013) Nodal Promotes mir206 Expression to Control Convergence and Extension Movements During Zebrafish Gastrulation. Journal of genetics and genomics = Yi chuan xue bao. 40(10):515-521

Xu, R.R., Zhang, C.W., Cao, Y., and Wang, Q. (2013) mir122 deficiency inhibits differentiation of zebrafish hepatoblast into hepatocyte. Yi chuan = Hereditas. 35(4):488-494

Ning, G., Liu, X., Dai, M., Meng, A., and Wang, Q. (2013) MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Developmental Cell. 24(3):283-295

Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nature communications. 4:1728

Liu, Z.T., Wei, S., and Wang, Q. (2012) The Nodal regulated dusp4 inhibits mesendoderm formation during zebrafish gastrulation. Yi chuan = Hereditas. 34(9):1153-1158

Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32

NON-ZEBRAFISH PUBLICATIONS
[1] Y. Li, X. Kang, and Q. Wang*, HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-beta-induced epithelial-mesenchymal transition. J Genet Genomics 38 (2011) 111-116. (Corresponding author)
[2] W. Zhang, Y. Jiang, Q. Wang, X. Ma, Z. Xiao, W. Zuo, X. Fang, and Y.G. Chen, Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization. Proc Natl Acad Sci U S A 106 (2009) 15679-15683.
[3] Q. Wang, Z. Huang, H. Xue, C. Jin, X.L. Ju, J.D. Han, and Y.G. Chen, MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 111 (2008) 588-595.
[4] J. Yu, Q. Wang, X. Shi, X. Ma, H. Yang, Y.G. Chen, and X. Fang, Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells. J Phys Chem B 111 (2007) 13619-13625.
[5] X. Ma, Q. Wang, Y. Jiang, Z. Xiao, X. Fang, and Y.G. Chen, Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging. Biochem Biophys Res Commun 356 (2007) 67-71.
[6] J. Ma*, Q. Wang*, T. Fei, J.D. Han, and Y.G. Chen, MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 109 (2007) 987-94. (*Co-first author)
[7] Y.G. Chen, Q. Wang, S.L. Lin, C.D. Chang, J. Chuang, and S.Y. Ying, Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp Biol Med (Maywood) 231 (2006) 534-44.
[8] Q. Wang, Z. Bai, X. Li, L. Hou, and B. Zhang, The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription. Cancer Lett 214 (2004) 81-90.
[9] J. Lv, H. Liu, Q. Wang, Z. Tang, L. Hou, and B. Zhang, Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. Biochem Biophys Res Commun 311 (2003) 506-13.