Freeman Lab

The interests of the Freeman laboratory are to define the underlying genetic and epigenetic mechanisms of toxicity of environmental stressors with current focus on pesticides, metals, radiation, and emerging contaminants. Projects are defining the immediate adverse impacts of a developmental exposure, the lasting adverse impacts of this developmental exposure throughout the lifespan, and the analysis of subsequent generations linking genetic, epigenetic, and phenotypic assessments. These studies are investigating the developmental origin of health and disease pathogenesis with a specific focus on neurological disorders, reproductive dysfunction, cardiovascular function, and cancer with a goal of understanding the role of exposure to the environmental stressors in these adverse health outcomes. All projects are currently utilizing the zebrafish vertebrate model system as a tool to investigate toxicity.