ZFIN ID: ZDB-LAB-050425-2
Amatruda Lab
PI/Director: Amatruda, James F.
Contact Person: Amatruda, James F.
Email: jamatruda@chla.usc.edu
URL:
Address: Cancer and Blood Disease Institute Division of Hematology-Oncology Children's Hospital Los Angeles Professor of Pediatrics and Medicine Keck School of Medicine University of Southern California
Country: United States
Phone: 323-361-9842
Fax:
Line Designation: sw


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
Cancer Susceptibility Genes
DNA Damage Response
Testicular Cancer Models


LAB MEMBERS
Moon, Jesung Post-Doc Neumann, Joanie Post-Doc Shukla, Abhay Post-Doc
Pierce, Joshua Graduate Student Sanchez, Angelica Graduate Student Budhipramono, Albert Technical Staff
Murchison, Whitney Technical Staff Stuart, Sarai Technical Staff Tucker, Kathryn Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Bhargava, V., Goldstein, C.D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J.F., Yanowitz, J.L., Buszczak, M. (2019) GCNA Preserves Genome Integrity and Fertility Across Species. Developmental Cell. 52(1):38-52.e10
Sanchez, A., Xu, L., Pierce, J.L., Lafin, J.T., Abe, D., Bagrodia, A., Frazier, A.L., Amatruda, J.F. (2019) Identification of testicular cancer driver genes by a cross-species comparative oncology approach. Andrology. 7(4):545-554
Bhakta, M., Padanad, M.S., Harris, J.P., Lubczyk, C., Amatruda, J.F., Munshi, N.V. (2018) pouC regulates expression of bmp4 during atrioventricular canal formation in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 248(2):173-188
Kendall, G.C., Watson, S., Xu, L., LaVigne, C.A., Murchison, W., Rakheja, D., Skapek, S.X., Tirode, F., Delattre, O., Amatruda, J.F. (2018) PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.. eLIFE. 7
Tiwari, B., Kurtz, P., Jones, A.E., Wylie, A., Amatruda, J.F., Boggupalli, D.P., Gonsalvez, G.B., Abrams, J.M. (2017) Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Current biology : CB. 27(19):3010-3016.e3
Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B., Amatruda, J.F. (2016) Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 7(42):67919-67933
Dranow, D.B., Hu, K., Bird, A.M., Lawry, S.T., Adams, M.T., Sanchez, A., Amatruda, J.F., Draper, B.W. (2016) Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genetics. 12:e1006323
Kendall, G.C., Amatruda, J.F. (2016) Zebrafish as a Model for the Study of Solid Malignancies. Methods in molecular biology (Clifton, N.J.). 1451:121-42
Moon, J., Amatruda, J.F. (2016) Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. Methods in molecular biology (Clifton, N.J.). 1481:95-100
Sanchez, A., Amatruda, J.F. (2016) Zebrafish Germ Cell Tumors. Advances in experimental medicine and biology. 916:479-94
Wylie, A., Jones, A.E., D'Brot, A., Lu, W.J., Kurtz, P., Moran, J.V., Rakheja, D., Chen, K.S., Hammer, R.E., Comerford, S.A., Amatruda, J.F., Abrams, J.M. (2016) p53 genes function to restrain mobile elements. Genes & Development. 30(1):64-77
Patton, E.E., Dhillon, P., Amatruda, J.F., Ramakrishnan, L. (2014) Spotlight on Zebrafish: Translational Impact. Disease models & mechanisms. 7:731-733
Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R.J., Cleaver, O., Levine, B., and Amatruda, J.F. (2014) Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 10(4):572-87
Wang, X., Moon, J., Dodge, M.E., Pan, X., Zhang, L., Hanson, J.M., Tuladhar, R., Ma, Z., Shi, H., Williams, N.S., Amatruda, J.F., Carroll, T.J., Lum, L., and Chen, C. (2013) The development of highly potent inhibitors for porcupine. Journal of medicinal chemistry. 56(6):2700-2704
Verduzco, D., Shepard Dovey, J., Shukla, A., Kodym, E., Skaug, B.A., and Amatruda, J.F. (2012) Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Molecular cancer research : MCR. 10(11):1451-1461
Dodge, M.E., Moon, J., Tuladhar, R., Lu, J., Jacob, L.S., Zhang, L.S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C.M., Carroll, T.J., Chen, C., Amatruda, J.F., and Lum, L. (2012) Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. The Journal of biological chemistry. 287(27):23246-23254
Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340
Hajeri, V.A., and Amatruda, J.F. (2012) Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Disease models & mechanisms. 5(1):33-7
Leacock, S.W., Basse, A.N., Chandler, G.L., Kirk, A.M., Rakheja, D., and Amatruda, J.F. (2012) A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Disease models & mechanisms. 5(1):95-106
Neumann, J.C., Chandler, G.L., Damoulis, V.A., Fustino, N.J., Lillard, K., Looijenga, L., Margraf, L., Rakheja, D., and Amatruda, J.F. (2011) Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13153-8
Neumann, J.C., Lillard, K., Damoulis, V., and Amatruda, J.F. (2011) Zebrafish models of germ cell tumor. Methods in cell biology. 105:1-24
Verduzco, D., and Amatruda, J.F. (2011) Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods in cell biology. 101:19-38
Mitchell, I.C., Brown, T.S., Terada, L.S., Amatruda, J.F., and Nwariaku, F.E. (2010) Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development. PLoS One. 5(1):e8807
Neumann, J.C., Dovey, J.S., Chandler, G.L., Carbajal, L., and Amatruda, J.F. (2009) Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 6(4):319-327
Rhodes, J., Amsterdam, A., Sanda, T., Moreau, L.A., McKenna, K., Heinrichs, S., Ganem, N.J., Ho, K.W., Neuberg, D.S., Johnston, A., Ahn, Y., Kutok, J.L., Hromas, R., Wray, J., Lee, C., Murphy, C., Radke, I., Downing, J.R., Fleming, M.D., Macconaill, L.E., Amatruda, J.F., Gutierrez, A., Galinsky, I., Stone, R.M., Ross, E.A., Pellman, D.S., Kanki, J.P., and Look, A.T. (2009) Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression. Molecular and cellular biology. 29(21):5911-5922
Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology. 5(2):100-107
Fan, L., Moon, J., Wong, T.T., Crodian, J., and Collodi, P. (2008) Zebrafish Primordial Germ Cell Cultures Derived from vasa::RFP Transgenic Embryos. Stem cells and development. 17(3):585-598
Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T. (2008) Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3. Cell. 133(5):864-877
Amatruda, J.F., and Patton, E.E. (2008) Chapter 1 genetic models of cancer in zebrafish. International review of cell and molecular biology. 271:1-34
Grzmil, M., Whiting, D., Maule, J., Anastasaki, C., Amatruda, J.F., Kelsh, R.N., Norbury, C.J., and Patton, E.E. (2007) The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development. PLoS One. 2(9):e959
Shepard, J.L., Amatruda, J.F., Finkelstein, D., Ziai, J., Finley, K.R., Stern, H.M., Chiang, K., Hersey, C., Barut, B., Freeman, J.L., Lee, C., Glickman, J.N., Kutok, J.L., Aster, J.C., and Zon, L.I. (2007) A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes & Development. 21(1):55-59
Fan, L., Moon, J., Crodian, J., and Collodi, P. (2006) Homologous Recombination in Zebrafish ES Cells. Transgenic Research. 15(1):21-30
Stern, H.M., Murphey, R.D., Shepard, J.L., Amatruda, J.F., Straub, C., Pfaff, K.L., Weber, G., Tallarico, J.A., King, R.W. and Zon, L.I. (2005) Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nature Chemical Biology. 1(7):366-370
Shepard, J.L., Amatruda, J.F., Stern, H.M., Subramanian, A., Finkelstein, D., Ziai, J., Finley, K.R., Pfaff, K.L., Hersey, C., Zhou, Y., Barut, B., Freedman, M., Lee, C., Spitsbergen, J., Neuberg, D., Weber, G., Golub, T.R., Glickman, J.N., Kutok, J.L., Aster, J.C., and Zon, L.I. (2005) A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 102(37):13194-13199
Biga, P.R., Roberts, S.B., Iliev, D.B., McCauley, L.A., Moon, J.S., Collodi, P., and Goetz, F.W. (2005) The isolation, characterization, and expression of a novel GDF11 gene and a second myostatin form in zebrafish, Danio rerio. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 141(2):218-230
Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., Aster, J.C., Granter, S.R., Look, A.T., Lee, C., Fisher, D.E., and Zon, L.I. (2005) BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma. Current biology : CB. 15(3):249-254
Shepard, J.L., Stern, H.M., Pfaff, K.L., and Amatruda, J.F. (2004) Analysis of the cell cycle in zebrafish embryos. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:109-125
Amatruda, J.F., Shepard, J.L., Stern, H.M., and Zon, L.I. (2002) Zebrafish as a cancer model system. Cancer Cell. 2(3):229-231
Amatruda, J.F. and Zon, L.I. (1999) Dissecting hematopoiesis and disease using the zebrafish. Developmental Biology. 216(1):1-15