ZFIN Person: Amatruda, James F.

ZFIN ID: ZDB-PERS-990322-6

Amatruda, James F.

Email:	jamatruda@chla.usc.edu
URL:
Affiliation:	Amatruda Lab
Address:	James F. Amatruda, M.D., Ph.D. Sarcoma Research Chair Cancer and Blood Disease Institute Division of Hematology-Oncology Children's Hospital Los Angeles Professor of Pediatrics and Medicine Keck School of Medicine University of Southern California
Country:	United States
Phone:	323-361-9842
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Watson, S., LaVigne, C.A., Xu, L., Surdez, D., Cyrta, J., Calderon, D., Cannon, M.V., Kent, M.R., Silvius, K.M., Kucinski, J.P., Harrison, E.N., Murchison, W., Rakheja, D., Tirode, F., Delattre, O., Amatruda, J.F., Kendall, G.C. (2023) VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. Cell Reports. 42:112013112013

Segal, D., Mazloom-Farsibaf, H., Chang, B.J., Roudot, P., Rajendran, D., Daetwyler, S., Fiolka, R., Warren, M., Amatruda, J.F., Danuser, G. (2022) In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish. The Journal of cell biology. 221(11):

Vasileva, E., Warren, M., Triche, T.J., Amatruda, J.F. (2022) Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth. eLIFE. 11:

Bhargava, V., Goldstein, C.D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J.F., Yanowitz, J.L., Buszczak, M. (2019) GCNA Preserves Genome Integrity and Fertility Across Species. Developmental Cell. 52(1):38-52.e10

Sanchez, A., Xu, L., Pierce, J.L., Lafin, J.T., Abe, D., Bagrodia, A., Frazier, A.L., Amatruda, J.F. (2019) Identification of testicular cancer driver genes by a cross-species comparative oncology approach. Andrology. 7(4):545-554

Bhakta, M., Padanad, M.S., Harris, J.P., Lubczyk, C., Amatruda, J.F., Munshi, N.V. (2018) pouC regulates expression of bmp4 during atrioventricular canal formation in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(2):173-188

Kendall, G.C., Watson, S., Xu, L., LaVigne, C.A., Murchison, W., Rakheja, D., Skapek, S.X., Tirode, F., Delattre, O., Amatruda, J.F. (2018) PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.. eLIFE. 7

Tiwari, B., Kurtz, P., Jones, A.E., Wylie, A., Amatruda, J.F., Boggupalli, D.P., Gonsalvez, G.B., Abrams, J.M. (2017) Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Current biology : CB. 27(19):3010-3016.e3

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B., Amatruda, J.F. (2016) Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 7(42):67919-67933

Dranow, D.B., Hu, K., Bird, A.M., Lawry, S.T., Adams, M.T., Sanchez, A., Amatruda, J.F., Draper, B.W. (2016) Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genetics. 12:e1006323

Moon, J., Amatruda, J.F. (2016) Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. Methods in molecular biology (Clifton, N.J.). 1481:95-100

Wylie, A., Jones, A.E., D'Brot, A., Lu, W.J., Kurtz, P., Moran, J.V., Rakheja, D., Chen, K.S., Hammer, R.E., Comerford, S.A., Amatruda, J.F., Abrams, J.M. (2016) p53 genes function to restrain mobile elements. Genes & Development. 30(1):64-77

Sanchez, A., Amatruda, J.F. (2016) Zebrafish Germ Cell Tumors. Advances in experimental medicine and biology. 916:479-94

Kendall, G.C., Amatruda, J.F. (2016) Zebrafish as a Model for the Study of Solid Malignancies. Methods in molecular biology (Clifton, N.J.). 1451:121-42

Patton, E.E., Dhillon, P., Amatruda, J.F., Ramakrishnan, L. (2014) Spotlight on Zebrafish: Translational Impact. Disease models & mechanisms. 7:731-733

Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R.J., Cleaver, O., Levine, B., and Amatruda, J.F. (2014) Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 10(4):572-87

Wang, X., Moon, J., Dodge, M.E., Pan, X., Zhang, L., Hanson, J.M., Tuladhar, R., Ma, Z., Shi, H., Williams, N.S., Amatruda, J.F., Carroll, T.J., Lum, L., and Chen, C. (2013) The development of highly potent inhibitors for porcupine. Journal of medicinal chemistry. 56(6):2700-2704

Verduzco, D., Shepard Dovey, J., Shukla, A., Kodym, E., Skaug, B.A., and Amatruda, J.F. (2012) Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Molecular cancer research : MCR. 10(11):1451-1461

Dodge, M.E., Moon, J., Tuladhar, R., Lu, J., Jacob, L.S., Zhang, L.S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C.M., Carroll, T.J., Chen, C., Amatruda, J.F., and Lum, L. (2012) Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. The Journal of biological chemistry. 287(27):23246-23254

Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340

Hajeri, V.A., and Amatruda, J.F. (2012) Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Disease models & mechanisms. 5(1):33-7

Leacock, S.W., Basse, A.N., Chandler, G.L., Kirk, A.M., Rakheja, D., and Amatruda, J.F. (2012) A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Disease models & mechanisms. 5(1):95-106

Neumann, J.C., Chandler, G.L., Damoulis, V.A., Fustino, N.J., Lillard, K., Looijenga, L., Margraf, L., Rakheja, D., and Amatruda, J.F. (2011) Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13153-8

Neumann, J.C., Lillard, K., Damoulis, V., and Amatruda, J.F. (2011) Zebrafish models of germ cell tumor. Methods in cell biology. 105:1-24

Verduzco, D., and Amatruda, J.F. (2011) Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods in cell biology. 101:19-38

Mitchell, I.C., Brown, T.S., Terada, L.S., Amatruda, J.F., and Nwariaku, F.E. (2010) Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development. PLoS One. 5(1):e8807

Neumann, J.C., Dovey, J.S., Chandler, G.L., Carbajal, L., and Amatruda, J.F. (2009) Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 6(4):319-327

Rhodes, J., Amsterdam, A., Sanda, T., Moreau, L.A., McKenna, K., Heinrichs, S., Ganem, N.J., Ho, K.W., Neuberg, D.S., Johnston, A., Ahn, Y., Kutok, J.L., Hromas, R., Wray, J., Lee, C., Murphy, C., Radke, I., Downing, J.R., Fleming, M.D., Macconaill, L.E., Amatruda, J.F., Gutierrez, A., Galinsky, I., Stone, R.M., Ross, E.A., Pellman, D.S., Kanki, J.P., and Look, A.T. (2009) Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression. Molecular and cellular biology. 29(21):5911-5922

Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology. 5(2):100-107

Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T. (2008) Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3. Cell. 133(5):864-877

Amatruda, J.F., and Patton, E.E. (2008) Chapter 1 genetic models of cancer in zebrafish. International review of cell and molecular biology. 271:1-34

Grzmil, M., Whiting, D., Maule, J., Anastasaki, C., Amatruda, J.F., Kelsh, R.N., Norbury, C.J., and Patton, E.E. (2007) The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development. PLoS One. 2(9):e959

Shepard, J.L., Amatruda, J.F., Finkelstein, D., Ziai, J., Finley, K.R., Stern, H.M., Chiang, K., Hersey, C., Barut, B., Freeman, J.L., Lee, C., Glickman, J.N., Kutok, J.L., Aster, J.C., and Zon, L.I. (2007) A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes & Development. 21(1):55-59

Stern, H.M., Murphey, R.D., Shepard, J.L., Amatruda, J.F., Straub, C., Pfaff, K.L., Weber, G., Tallarico, J.A., King, R.W. and Zon, L.I. (2005) Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nature Chemical Biology. 1(7):366-370

Shepard, J.L., Amatruda, J.F., Stern, H.M., Subramanian, A., Finkelstein, D., Ziai, J., Finley, K.R., Pfaff, K.L., Hersey, C., Zhou, Y., Barut, B., Freedman, M., Lee, C., Spitsbergen, J., Neuberg, D., Weber, G., Golub, T.R., Glickman, J.N., Kutok, J.L., Aster, J.C., and Zon, L.I. (2005) A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 102(37):13194-13199

Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., Aster, J.C., Granter, S.R., Look, A.T., Lee, C., Fisher, D.E., and Zon, L.I. (2005) BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma. Current biology : CB. 15(3):249-254

Shepard, J.L., Stern, H.M., Pfaff, K.L., and Amatruda, J.F. (2004) Analysis of the cell cycle in zebrafish embryos. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:109-125

Amatruda, J.F., Shepard, J.L., Stern, H.M., and Zon, L.I. (2002) Zebrafish as a cancer model system. Cancer Cell. 2(3):229-231

Amatruda, J.F. and Zon, L.I. (1999) Dissecting hematopoiesis and disease using the zebrafish. Developmental Biology. 216(1):1-15

NON-ZEBRAFISH PUBLICATIONS