Phenotype: broad specificity oxidative DNA demethylase activity disrupted, abnormal
Note: This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.
Name: broad specificity oxidative DNA demethylase activity
Synonyms: 1-ethyladenine demethylase activity, 2-oxoglutarate-dependent DNA demethylase, 5-formylcytosine dioxygenase activity, 5-hydroxymethylcytosine dioxygenase activity, N1-methyladenine demethylase activity, N3-methylcytosine demethylase activity, oxidative DNA demethylase activity
Definition: Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
Ontology: GO: Molecular Function [GO:0035516]    QuickGO    AmiGO
Name: disrupted
Synonyms:
Definition: A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course.
Ontology: Phenotypic Quality Ontology [PATO:0001507]
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