broad specificity oxidative DNA demethylase activity

Term ID

GO:0035516

Synonyms

• 1-ethyladenine demethylase activity
• 2-oxoglutarate-dependent DNA demethylase
• 5-formylcytosine dioxygenase activity
• 5-hydroxymethylcytosine dioxygenase activity
• N1-methyladenine demethylase activity
• N3-methylcytosine demethylase activity
• oxidative DNA demethylase activity

Definition

Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. (4)

References

• EC:1.14.11.33
• MetaCyc:RXN-12353
• RHEA:30299
• Reactome:R-HSA-112118
• Reactome:R-HSA-112123

Ontology

GO: Molecular Function    QuickGO    AmiGO