| Phenotype: | MAPK cascade disrupted, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | MAPK cascade |
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| Synonyms: | ERK/MAPK cascade, MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPK signaling, MAPK signalling, MAPKKK cascade, MAPKKK cascade during sporulation, mitogen-activated protein kinase cascade |
| Definition: | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| Ontology: | GO: Biological Process [GO:0000165] QuickGO AmiGO |
| Name: | disrupted |
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| Synonyms: | |
| Definition: | A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001507] |