| Phenotype: | thymus rag1 expression decreased distribution, abnormal |
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| Note: | This phenotype statement describes a gene expression or antibody labeling pattern. Anatomy terms are combined with a gene or antibody and phenotype quality. |
EXPRESSION ANATOMY:
| Name: | thymus |
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| Synonyms: | |
| Definition: | Paired organ where maturation of T-lymphocytes occurs. The adult thymus located on the dorsomedial aspect of the branchial cavity above the third pharyngeal cartilage. The thymus undergoes a period of rapid growth beginning at about the third week and continuing for several more weeks. Accompanying this growth is a dramatic change in the shape of the thymus. It is ovoid initially and then starts to grow dorsally along the skull, forming a characteristic protrusion. During this growth period the adult pattern of rag1-positive cortex and rag1-negative medulla becomes established. The protrusions diminish with age and the thymus gradually shrinks; at two years, the thymus is again confined to the pharynx with minimal if any protrusion. |
| Ontology: | Anatomy Ontology [ZFA:0001078] |
EXPRESSED GENE:
| Symbol: | rag1 | ||||||||||||
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| Name: | recombination activating 1 | ||||||||||||
| Previous Names: | etID309719.25 (1), recombinase | ||||||||||||
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| Location: | Chr: 25 Mapping Details/Browsers | ||||||||||||
EXPRESSION QUALITY:
| Name: | decreased distribution |
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| Synonyms: | low distribution |
| Definition: | A distribution which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001672] |