OBO ID: CHEBI:59729
Term Name: fenfluramine hydrochloride Search Ontology:
Synonyms:
  • (+-)-fenfluramine HCl
  • (+-)-fenfluramine hydrochloride
  • 1-(3-trifluoromethylphenyl)-2-ethylaminopropane hydrochloride
  • fenfluramine HCl
  • N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride
  • N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-aminium chloride
  • N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
  • NN-ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride
Definition: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
References:
  • Beilstein:5652886
  • CAS:404-82-0
  • DrugBank:DB00574
  • KEGG:D04148
Ontology: Chebi
PHENOTYPE No data available