Search Ontology:
ChEBI

fenfluramine

Term ID
CHEBI:5000
Synonyms
  • (+-)-fenfluramine
  • 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
  • 2-ethylamino-1-(3-trifluoromethylphenyl)propane
  • 3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
  • Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine
  • Fenfluramine
  • fenfluraminum
  • N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine
  • N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
  • N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine
Definition
A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has subtype
has_role
inverse has_part
Phenotype
Phenotype resulting from fenfluramine
Phenotype where environments contain fenfluramine
Phenotype modified by environments containing fenfluramine
Human Disease Model