Gene
egr1
- ID
- ZDB-GENE-980526-320
- Name
- early growth response 1
- Symbol
- egr1 Nomenclature History
- Previous Names
-
- etID309970.14 (1)
- krox-24
- krox24
- wu:fj64b05
- wu:fq25f01
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including double-stranded DNA binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in retina layer formation. Acts upstream of or within embryonic retina morphogenesis in camera-type eye; embryonic viscerocranium morphogenesis; and glial cell development. Predicted to be located in cytoplasm and nucleus. Is expressed in head; heart; hindbrain neural keel; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a264 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ihb423 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| ihb424 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| sa64 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa66 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa469 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| stl667 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Early growth response, N-terminal | Early growth response protein 1, C-terminal | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
| UniProtKB:P26632 | InterPro | 511 | ||||
| UniProtKB:B3DKJ7 | InterPro | 511 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(egr1-Mmu.Fos:GFP) |
|
| 2 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-119C17 | ZFIN Curated Data | |
| Encodes | EST | fj64b05 | ||
| Encodes | EST | fq25f01 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:195300 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131248 (1) | 1536 nt | ||
| Genomic | GenBank:CR925789 (1) | 173071 nt | ||
| Polypeptide | UniProtKB:B3DKJ7 (1) | 511 aa |
- Hosaka, S., Hosokawa, M., Hibi, M., Shimizu, T. (2024) The zebrafish cerebellar neural circuits are involved in orienting behavior. eNeuro. 11(10):
- Peterson, E.A., Sun, J., Chen, X., Wang, J. (2024) Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Developmental Biology. 508:93-106
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Xie, J., Goodbourn, P.T., Bui, B.V., Jusuf, P.R. (2024) Establishment and comprehensive characterization of a novel dark-reared zebrafish model for myopia studies. Experimental Eye Research. 246:110009
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Rafique, H., Hu, X., Ren, T., Dong, R., Aadil, R.M., Zou, L., Sharif, M.K., Li, L. (2023) Characterization and Exploration of the Neuroprotective Potential of Oat-Protein-Derived Peptides in PC12 Cells and Scopolamine-Treated Zebrafish. Nutrients. 16(1):
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Tallafuss, A., Stednitz, S.J., Voeun, M., Levichev, A., Larsch, J., Eisen, J., Washbourne, P. (2022) Egr1 is necessary for forebrain dopaminergic signaling during social behavior. eNeuro. 9(2):
- Vignes, H., Vagena-Pantoula, C., Prakash, M., Fukui, H., Norden, C., Mochizuki, N., Jug, F., Vermot, J. (2022) Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Developmental Cell. 57(5):598-609.e5
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
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