Gene
srgap2
- ID
- ZDB-GENE-060915-2
- Name
- SLIT-ROBO Rho GTPase activating protein 2
- Symbol
- srgap2 Nomenclature History
- Previous Names
-
- srgap2
- srgap2a
- wu:fb47h12
- zgc:136814
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity; Rac GTPase binding activity; and protein homodimerization activity. Predicted to be involved in actin filament severing; filopodium assembly; and generation of neurons. Predicted to localize to several cellular components, including dendritic spine head; phagocytic vesicle; and postsynaptic density. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pan et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pan et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035648 | srGAP1/2/3, SH3 domain |
| Family | IPR051627 | SLIT-ROBO Rho GTPase-activating |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | SLIT-ROBO Rho GTPase-activating | srGAP1/2/3, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0S6J3
|
1100 | |||||||||
|
UniProtKB:A0A8M2BK74
|
1091 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srgap2-201
(1)
|
Ensembl | 7,297 nt | ||
| mRNA |
srgap2-203
(1)
|
Ensembl | 7,836 nt | ||
| mRNA |
srgap2-204
(1)
|
Ensembl | 8,294 nt | ||
| ncRNA |
srgap2-002
(1)
|
Ensembl | 818 nt |
Interactions and Pathways
No data available
Plasmids
No data available