Gene

phf8

ID

ZDB-GENE-060419-1

Name

PHD finger protein 8

Symbol

phf8 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have chromatin binding activity; histone demethylase activity; and methylated histone binding activity. Involved in several processes, including embryonic organ development; positive regulation of transcription, DNA-templated; and regulation of neuron apoptotic process. Predicted to localize to nucleolus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Siderius type. Is expressed in head; mandibular arch skeleton; and tail bud. Orthologous to human PHF8 (PHD finger protein 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With phf8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked intellectual disability Siderius type	Alliance	Intellectual developmental disorder, X-linked syndromic, Siderius type	300263

Associated With phf8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR003347	JmjC domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR041070	Jumonji, helical domain
Family	IPR050690	JHDM1 Histone Demethylase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type