Gene

isca1

ID

ZDB-GENE-050626-94

Name

iron-sulfur cluster assembly 1

Symbol

isca1 Nomenclature History

Previous Names

magr (1)
zgc:114185

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Acts upstream of or within heme biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nilsson et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With isca1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple mitochondrial dysfunctions syndrome 5	Alliance	Multiple mitochondrial dysfunctions syndrome 5	617613

Associated With isca1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017870	FeS cluster insertion, C-terminal, conserved site
Domain	IPR000361	FeS cluster biogenesis
Family	IPR016092	FeS cluster insertion protein
Family	IPR050322	Iron-sulfur cluster assembly and transfer HesB/IscA
Homologous_superfamily	IPR035903	HesB-like domain superfamily

Domain Details Per Protein

Protein	Length	FeS cluster biogenesis	FeS cluster insertion, C-terminal, conserved site	FeS cluster insertion protein	HesB-like domain superfamily	Iron-sulfur cluster assembly and transfer HesB/IscA
UniProtKB:Q4QRC6 InterPro	129

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	isca1-201 (1) Ensembl	Ensembl		3,628 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations