Gene

trip12

ID

ZDB-GENE-041111-262

Name

thyroid hormone receptor interactor 12

Symbol

trip12 Nomenclature History

Previous Names

im:7149446
si:ch211-272f3.4 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; cellular response to DNA damage stimulus; and negative regulation of nitrogen compound metabolic process. Predicted to localize to nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 49. Is expressed in myotome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149446 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trip12 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Clark-Baraitser syndrome	Alliance	Intellectual developmental disorder, autosomal dominant 49	617752

Associated With trip12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000569	HECT domain
Domain	IPR004170	WWE domain
Domain	IPR018123	WWE domain, subgroup
Family	IPR045322	E3 ubiquitin-protein ligase HECTD1/TRIP12-like
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR037197	WWE domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	E3 ubiquitin-protein ligase HECTD1/TRIP12-like	HECT domain	HECT, E3 ligase catalytic domain	WWE domain	WWE domain, subgroup	WWE domain superfamily
UniProtKB:F1RCR6 InterPro	2026
UniProtKB:A0A8M2B5R0 InterPro	2054
UniProtKB:A0A8M1P4D4 InterPro	2053
UniProtKB:A0A8M2B655 InterPro	2096
UniProtKB:A0A8M9PA43 InterPro	1666
UniProtKB:A0A8M2B5U3 InterPro	2095

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	trip12-201 (1) Ensembl	Ensembl	7,723 nt	Select Tool ZFIN BLAST
mRNA	trip12-202 (1) Ensembl	Ensembl	258 nt	Select Tool
mRNA	trip12-203 (1) Ensembl	Ensembl	6,552 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations