Gene
mus81
- ID
- ZDB-GENE-040426-2923
- Name
- MUS81 structure-specific endonuclease subunit
- Symbol
- mus81 Nomenclature History
- Previous Names
-
- wu:fc26g01
- zgc:66489
- zgc:91801
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to contribute to crossover junction endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via break-induced replication; intra-S DNA damage checkpoint; and resolution of meiotic recombination intermediates. Predicted to localize to Holliday junction resolvase complex and nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66489 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006166 | ERCC4 domain |
| Domain | IPR047416 | MUS81, XPF-like nuclease domain |
| Domain | IPR047417 | MUS81, winged helix domain |
| Family | IPR033309 | Crossover junction endonuclease Mus81 |
| Homologous_superfamily | IPR011335 | Restriction endonuclease type II-like |
| Homologous_superfamily | IPR027421 | DNA polymerase lambda lyase domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR042530 | EME1/EME2, C-terminal domain |
Domain Details Per Protein
| Protein | Length | Crossover junction endonuclease Mus81 | DNA polymerase lambda lyase domain superfamily | EME1/EME2, C-terminal domain | ERCC4 domain | MUS81, winged helix domain | MUS81, XPF-like nuclease domain | Restriction endonuclease type II-like | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6GML8
|
612 | ||||||||
|
UniProtKB:Q7SXA9
|
604 |
Interactions and Pathways
No data available
Plasmids
No data available