Gene
spast
- ID
- ZDB-GENE-040426-2331
- Name
- spastin
- Symbol
- spast Nomenclature History
- Previous Names
-
- spg4 (1)
- zgc:85952
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have microtubule-severing ATPase activity and tubulin binding activity. Involved in several processes, including cytoplasmic microtubule organization; generation of neurons; and positive regulation of microtubule depolymerization. Predicted to colocalize with microtubule cytoskeleton. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85952 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 4 | Alliance | Spastic paraplegia 4, autosomal dominant | 182601 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hereditary spastic paraplegia | WT + MO3-spast | standard conditions | Julien et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR007330 | MIT domain |
| Domain | IPR015415 | Spastin/Vps4, C-terminal |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR017179 | Spastin |
| Family | IPR035106 | Spastin, chordate |
| Family | IPR050304 | Microtubule-severing AAA ATPase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Microtubule-severing AAA ATPase | MIT domain | P-loop containing nucleoside triphosphate hydrolase | Spastin | Spastin, chordate | Spastin/Vps4, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B2A7
|
543 | ||||||||||
|
UniProtKB:Q6NW58
|
570 |
Interactions and Pathways
No data available
Plasmids
No data available