Gene

spast

ID

ZDB-GENE-040426-2331

Name

spastin

Symbol

spast Nomenclature History

Previous Names

spg4 (1)
zgc:85952

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable microtubule severing ATPase activity and tubulin binding activity. Acts upstream of or within several processes, including axonogenesis; positive regulation of cellular component organization; and skeletal muscle fiber development. Predicted to be located in midbody and nuclear membrane. Predicted to be active in microtubule cytoskeleton. Is expressed in brain; fat cell; heart; liver; and muscle. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:85952 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spast Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 4	Alliance	Spastic paraplegia 4, autosomal dominant	182601

Associated With spast Via Experimental Models

Human Disease	Fish	Conditions	Citations
hereditary spastic paraplegia	WT + MO3-spast	standard conditions	Julien et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR007330	MIT domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR017179	Spastin
Family	IPR035106	Spastin, chordate
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase