Gene
spast
- ID
- ZDB-GENE-040426-2331
- Name
- spastin
- Symbol
- spast Nomenclature History
- Previous Names
-
- spg4 (1)
- zgc:85952
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule severing ATPase activity; and tubulin binding activity. Acts upstream of or within several processes, including axonogenesis; positive regulation of cellular component organization; and skeletal muscle fiber development. Predicted to be located in midbody and nuclear membrane. Predicted to be active in cytoplasm and spindle. Predicted to colocalize with microtubule cytoskeleton. Is expressed in brain; fat cell; heart; liver; and muscle. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85952 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hereditary spastic paraplegia 4 | Alliance | Spastic paraplegia 4, autosomal dominant | 182601 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
hereditary spastic paraplegia | WT + MO3-spast | standard conditions | Julien et al., 2016 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR003959 | ATPase, AAA-type, core |
Domain | IPR007330 | MIT domain |
Domain | IPR015415 | Spastin/Vps4, C-terminal |
Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
Family | IPR017179 | Spastin |
Family | IPR035106 | Spastin, chordate |
Family | IPR050304 | Microtubule-severing AAA ATPase |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Microtubule-severing AAA ATPase | MIT domain | P-loop containing nucleoside triphosphate hydrolase | Spastin | Spastin, chordate | Spastin/Vps4, C-terminal |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B2A7 | InterPro | 543 | ||||||||||
UniProtKB:Q6NW58 | InterPro | 570 |
Interactions and Pathways
No data available
Plasmids
No data available