Gene
spast
- ID
- ZDB-GENE-040426-2331
- Name
- spastin
- Symbol
- spast Nomenclature History
- Previous Names
-
- spg4 (1)
- zgc:85952
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have microtubule-severing ATPase activity and tubulin binding activity. Involved in several processes, including axonogenesis; cytoplasmic microtubule organization; and positive regulation of cellular component organization. Predicted to localize to microtubule cytoskeleton; midbody; and nuclear membrane. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85952 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 4 | Alliance | Spastic paraplegia 4, autosomal dominant | 182601 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hereditary spastic paraplegia | WT + MO3-spast | standard conditions | Julien et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR007330 | MIT domain |
| Domain | IPR015415 | Spastin/Vps4, C-terminal |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR017179 | Spastin |
| Family | IPR035106 | Spastin, chordate |
| Family | IPR050304 | Microtubule-severing AAA ATPase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Microtubule-severing AAA ATPase | MIT domain | P-loop containing nucleoside triphosphate hydrolase | Spastin | Spastin, chordate | Spastin/Vps4, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B2A7
|
543 | ||||||||||
|
UniProtKB:Q6NW58
|
570 |
Interactions and Pathways
No data available
Plasmids
No data available