Gene
glrx5
- ID
- ZDB-GENE-040426-1957
- Name
- glutaredoxin 5 homolog (S. cerevisiae)
- Symbol
- glrx5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have several functions, including 2 iron, 2 sulfur cluster binding activity; electron transfer activity; and protein disulfide oxidoreductase activity. Involved in hemopoiesis and iron-sulfur cluster assembly. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Is expressed in cardiovascular system; immature eye; intermediate cell mass of mesoderm; and liver. Orthologous to human GLRX5 (glutaredoxin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive pyridoxine-refractory sideroblastic anemia 3 | Alliance | Anemia, sideroblastic, 3, pyridoxine-refractory | 616860 |
| Spasticity, childhood-onset, with hyperglycinemia | 616859 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutaredoxin | Glutaredoxin, PICOT-like | Monothiol glutaredoxin-related | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q6PBM1
|
155 |
Interactions and Pathways
No data available
Plasmids
No data available