Gene

rpa1

ID

ZDB-GENE-030912-3

Name

replication protein A1

Symbol

rpa1 Nomenclature History

Previous Names

wu:fi14b08
zgc:55337
zgc:77092 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have damaged DNA binding activity and single-stranded telomeric DNA binding activity. Involved in heart development. Predicted to localize to DNA replication factor A complex and nuclear chromosome, telomeric region. Is expressed in head and pectoral fin. Orthologous to human RPA1 (replication protein A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55337 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rpa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	619767

Associated With rpa1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Domain	IPR007199	Replication factor-A protein 1, N-terminal
Domain	IPR013955	Replication factor A, C-terminal
Domain	IPR031657	Replication protein A, OB domain
Domain	IPR047192	Replication factor A, C-terminal, eukaryotes
Family	IPR004591	Replication factor A protein 1
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold