Gene
sdhaf2
- ID
- ZDB-GENE-030131-7564
- Name
- succinate dehydrogenase complex assembly factor 2
- Symbol
- sdhaf2 Nomenclature History
- Previous Names
-
- wu:fj30e04
- zgc:163000
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in aerobic respiration; mitochondrial respiratory chain complex II assembly; and protein-FAD linkage. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 2 | 601650 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Flavinator of succinate dehydrogenase | Flavinator of succinate dehydrogenase superfamily | Succinate dehydrogenase assembly factor 2, mitochondrial |
|---|---|---|---|---|---|
| UniProtKB:A3KP74 | InterPro | 158 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sdhaf2-201
(1)
|
Ensembl | 2,373 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-119P20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-132L2 | ZFIN Curated Data | |
| Encodes | EST | fj30e04 | ||
| Encodes | cDNA | MGC:163000 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082864 (1) | 821 nt | ||
| Genomic | GenBank:CT030046 | 174189 nt | ||
| Polypeptide | UniProtKB:A3KP74 (1) | 158 aa |
- Chai, T., Cui, F., Mu, P., Yang, Y., Xu, N., Yin, Z., Jia, Q., Yang, S., Qiu, J., Wang, C. (2016) Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149. Scientific Reports. 6:19478
- Chai, T., Cui, F., Mu, X., Yang, Y., Wang, C., Qiu, J. (2016) Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels. PLoS One. 11:e0155263
- Weger, B.D., Sahinbas, M., Otto, G.W., Mracek, P., Armant, O., Dolle, D., Lahiri, K., Vallone, D., Ettwiller, L., Geisler, R., Foulkes, N.S., and Dickmeis, T. (2011) The light responsive transcriptome of the zebrafish: function and regulation. PLoS One. 6(2):e17080
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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